lvrachЛечащий ВрачLechaschi Vrach1560-51752687-1181lvrach-316Research ArticleСтатьиГенетические аспекты формирования неалкогольной жировой болезни печениGenetic aspects of non-alcoholic fatty liver disease developmentАхмедовВ. А.AkhmedovV. A.v_akhmedov@mail.ruМеликовТ. И.MelikovT. I.noemail@neicon.ruФГБОУ ВО ОмГМУ МЗ РФRussian Federation201923062021082828Copyright © Ахмедов В.А., Меликов Т.И., 20212021Ахмедов В.А., Меликов Т.И.Akhmedov V.A., Melikov T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.lvrach.ru/jour/article/view/316

Прогрессирование неалкогольной жировой болезни печени (НАЖБП) определяется генетической восприимчивостью, факторами окружающей среды, образом жизни и особенностями метаболического синдрома, многие из которых пересекаются с гепатоцеллюлярной карциномой. Тем не менее многофакторная природа НАЖБП и ограниченное количество достаточно мощных исследований являются одними из текущих ограничений для подтвержденных биомаркеров клинической полезности. Дальнейшие исследования, включающие связи между циркадной регуляцией и печеночным метаболизмом, могут представлять дополнительное направление в поиске прогностических биомаркеров прогрессирования заболеваний печени и результатов лечения.

Progression of non-alcoholic fatty liver disease (NAFLD) is conditioned by genetic susceptibility, environmental factors, lifestyle and features of the metabolic syndrome, many of which overlap with hepatocellular carcinoma. However, the multifactorial nature of NAFLD and the limited number of sufficiently powerful studies are among the current limitations for validated biomarkers of clinical utility. Further studies incorporating the links between circadian regulation and hepatic metabolism may represent an additional direction in the search for predictive biomarkers of liver disease progression and treatment outcomes. 

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The authors declare that there are no conflicts of interest present.