<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">lvrach-313</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Современная стратегия ведения пациента с предраковыми заболеваниями желудка: диагностические подходы и терапевтические возможности</article-title><trans-title-group xml:lang="en"><trans-title>Modern strategy of patient management in pre-cancer stomach diseases: diagnostic approaches and therapeutic possibilities</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазебник</surname><given-names>Л. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazebnik</surname><given-names>L. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лялюкова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyalyukova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">lyalykova@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ВО МГМСУ им. А. И. Евдокимова МЗ РФ</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГБОУ ВО ОмГМУ МЗ РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>8</issue><fpage>7</fpage><lpage>7</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лазебник Л.Б., Лялюкова Е.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Лазебник Л.Б., Лялюкова Е.А.</copyright-holder><copyright-holder xml:lang="en">Lazebnik L.B., Lyalyukova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/313">https://journal.lvrach.ru/jour/article/view/313</self-uri><abstract><p>Рак желудка представляет серьезную медицинскую и социальную проблему как для большинства стран мира, так и для России. Пациенты с хроническим атрофическим гастритом или кишечной метаплазией имеют повышенный риск развития аденокарциномы желудка. В обзоре обобщены существующие международные рекомендации по ведению пациентов с атрофическим гастритом, кишечной метаплазией и дисплазией желудка.</p></abstract><trans-abstract xml:lang="en"><p>Stomach cancer represents a serious medical and social problem, both for most of the countries, and for Russia. Patients with chronic atrophic gastritis or intestinal metaplasia have increased risk of stomach adenocarcinoma development. This review summarizes the available international guidelines of patient management in atrophic gastritis, intestinal metaplasia and stomach dysplasia. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Гастроэнтерология</kwd><kwd>Кишечная метаплазия</kwd><kwd>Предрак желудка</kwd><kwd>Хронический атрофический гастрит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stomach pre-cancer</kwd><kwd>chronic atrophic gastritis</kwd><kwd>intestinal metaplasia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bray F., Ferlay J., Soerjomataram I. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries // CA Cancer J Clin. 2018; 68: 393-424.</mixed-citation><mixed-citation xml:lang="en">Bray F., Ferlay J., Soerjomataram I. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries // CA Cancer J Clin. 2018; 68: 393-424.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Areia M., Spaander M. C., Kuipers E. J. et al. Endoscopic screening for gastric cancer: A cost-utility analysis for countries with an intermediate gastric cancer risk // United European Gastroenterol J. 2018; 6: 192-202.</mixed-citation><mixed-citation xml:lang="en">Areia M., Spaander M. C., Kuipers E. J. et al. Endoscopic screening for gastric cancer: A cost-utility analysis for countries with an intermediate gastric cancer risk // United European Gastroenterol J. 2018; 6: 192-202.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Состояние онкологической помощи населению России в 2018 году / Под ред. А. Д. Каприна, В. В. Старинского, Г. В. Петровой. М.: МНИОИ им. П. А. Герцена, филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2019. 236 с.</mixed-citation><mixed-citation xml:lang="en">Состояние онкологической помощи населению России в 2018 году / Под ред. А. Д. Каприна, В. В. Старинского, Г. В. Петровой. М.: МНИОИ им. П. А. Герцена, филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2019. 236 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pimentel-Nunes P., Libanio D., Marcos-Pinto R., Areia M., Leja M., Esposito G., Garrido M., Kikuste I., Megraud F., Matysiak-Budnik T., Annibale B., Dumonceau J.-M., Barros R., Flejou J.-F., Carneiro F., van Hooft J. E., Kuipers E. J., Dinis-Ribeiro M., Pedro P.-N. et al. Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019 // Endoscopy. 2019; 51.</mixed-citation><mixed-citation xml:lang="en">Pimentel-Nunes P., Libanio D., Marcos-Pinto R., Areia M., Leja M., Esposito G., Garrido M., Kikuste I., Megraud F., Matysiak-Budnik T., Annibale B., Dumonceau J.-M., Barros R., Flejou J.-F., Carneiro F., van Hooft J. E., Kuipers E. J., Dinis-Ribeiro M., Pedro P.-N. et al. Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019 // Endoscopy. 2019; 51.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Рак желудка. Министерство здравоохранения РФ, 2018 г.</mixed-citation><mixed-citation xml:lang="en">Клинические рекомендации. Рак желудка. Министерство здравоохранения РФ, 2018 г.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Post R. S., Vogelaar I. P., Carneiro F. et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers // J Med Genet. 2015; 52: 361-374.</mixed-citation><mixed-citation xml:lang="en">Van der Post R. S., Vogelaar I. P., Carneiro F. et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers // J Med Genet. 2015; 52: 361-374.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Correa P. Human gastric carcinogenesis: a multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention // Cancer Res. 1992; 52: 6735-6740.</mixed-citation><mixed-citation xml:lang="en">Correa P. Human gastric carcinogenesis: a multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention // Cancer Res. 1992; 52: 6735-6740.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kapadia C. R. Gastric atrophy, metaplasia and dysplasia: a clinical perspective // J Clin Gastroenterol. 2003; 36: S29-36.</mixed-citation><mixed-citation xml:lang="en">Kapadia C. R. Gastric atrophy, metaplasia and dysplasia: a clinical perspective // J Clin Gastroenterol. 2003; 36: S29-36.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Carneiro F., Machado J. C., David L. et al. Current thoughts on the histo- pathogenesis of gastric cancer // Eur J Cancer Prev. 2001; 10: 101-102.</mixed-citation><mixed-citation xml:lang="en">Carneiro F., Machado J. C., David L. et al. Current thoughts on the histo- pathogenesis of gastric cancer // Eur J Cancer Prev. 2001; 10: 101-102.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ihamaki T., Sankkonen M., Siurala M. Long-term observation of subjects with normal mucosa and with superficial gastritis: results of 23-27 years’ follow-up examinations // Scand J Gastroenterol. 1978; 13: 771-775.</mixed-citation><mixed-citation xml:lang="en">Ihamaki T., Sankkonen M., Siurala M. Long-term observation of subjects with normal mucosa and with superficial gastritis: results of 23-27 years’ follow-up examinations // Scand J Gastroenterol. 1978; 13: 771-775.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ormiston M. C., Gear M. W., Codling B. W. Five year follow-up study of gastritis // J Clin Pathol. 1982; 35: 757-760.</mixed-citation><mixed-citation xml:lang="en">Ormiston M. C., Gear M. W., Codling B. W. Five year follow-up study of gastritis // J Clin Pathol. 1982; 35: 757-760.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yue H., Shan L., Bin L. The significance of OLGA and OLGIM staging systems in the risk assessment of gastric cancer: a systematic review and meta-analysis // Gastric Cancer. 2018; 21: 579-587. Epub 19 февраля 2018 г.</mixed-citation><mixed-citation xml:lang="en">Yue H., Shan L., Bin L. The significance of OLGA and OLGIM staging systems in the risk assessment of gastric cancer: a systematic review and meta-analysis // Gastric Cancer. 2018; 21: 579-587. Epub 19 февраля 2018 г.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Correa P. Clinical implications of recent developments in gastric cancer pathology and epidemiology // Semin Oncol. 1985; 12: 2-1025.</mixed-citation><mixed-citation xml:lang="en">Correa P. Clinical implications of recent developments in gastric cancer pathology and epidemiology // Semin Oncol. 1985; 12: 2-1025.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lauwers G., Carneiro F., Graham D. et al. Gastric carcinoma. In: Theise N, ed. WHO Classification of tumours of the digestive system. Lyon: IARC Press; 2010: 48-58.</mixed-citation><mixed-citation xml:lang="en">Lauwers G., Carneiro F., Graham D. et al. Gastric carcinoma. In: Theise N, ed. WHO Classification of tumours of the digestive system. Lyon: IARC Press; 2010: 48-58.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Goo J. J., Choi C. W., Kang D. H. et al. Risk factors associated with diagnostic discrepancy of gastric indefinite neoplasia: Who need en bloc resection? // Surg Endosc. 2015; 29: 3761-3767.</mixed-citation><mixed-citation xml:lang="en">Goo J. J., Choi C. W., Kang D. H. et al. Risk factors associated with diagnostic discrepancy of gastric indefinite neoplasia: Who need en bloc resection? // Surg Endosc. 2015; 29: 3761-3767.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao G., Xue M., Hu Y. et al. How commonly is the diagnosis of gastric low grade dysplasia upgraded following endoscopic resection? A meta-analysis // PLoS One. 2015; 10: e0132699.</mixed-citation><mixed-citation xml:lang="en">Zhao G., Xue M., Hu Y. et al. How commonly is the diagnosis of gastric low grade dysplasia upgraded following endoscopic resection? A meta-analysis // PLoS One. 2015; 10: e0132699.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Oliveira C., Pinheiro H., Figueiredo J. et al. Familial gastric cancer: genetic susceptibility, pathology, and implications for management // Lancet Oncol. 2015; 16: e60-e70.</mixed-citation><mixed-citation xml:lang="en">Oliveira C., Pinheiro H., Figueiredo J. et al. Familial gastric cancer: genetic susceptibility, pathology, and implications for management // Lancet Oncol. 2015; 16: e60-e70.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Yaghoobi M., Bijarchi R., Narod S. A. Family history and the risk of gastric cancer // Br J Cancer. 2010; 102: 237-242.</mixed-citation><mixed-citation xml:lang="en">Yaghoobi M., Bijarchi R., Narod S. A. Family history and the risk of gastric cancer // Br J Cancer. 2010; 102: 237-242.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Safaee A., Moghimi-Dehkordi B., Fatemi S. R. et al. Family history of cancer and risk of gastric cancer in Iran // Asian Pac J Cancer Prev. 2011; 12: 3117-3120.</mixed-citation><mixed-citation xml:lang="en">Safaee A., Moghimi-Dehkordi B., Fatemi S. R. et al. Family history of cancer and risk of gastric cancer in Iran // Asian Pac J Cancer Prev. 2011; 12: 3117-3120.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rokkas T., Sechopoulos P., Pistiolas D. et al. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis // Eur J Gastroenterol Hepatol. 2010; 22: 1128-1133.</mixed-citation><mixed-citation xml:lang="en">Rokkas T., Sechopoulos P., Pistiolas D. et al. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis // Eur J Gastroenterol Hepatol. 2010; 22: 1128-1133.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Marcos-Pinto R., Carneiro F., Dinis-Ribeiro M. et al. First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia // Aliment Pharmacol Ther. 2012; 35: 1451-1459.</mixed-citation><mixed-citation xml:lang="en">Marcos-Pinto R., Carneiro F., Dinis-Ribeiro M. et al. First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia // Aliment Pharmacol Ther. 2012; 35: 1451-1459.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy K. M., Chang J. I., Shi J. M. et al. Risk of gastric cancer among patients with intestinal metaplasia of the stomach in a US integrated health care system // Clin Gastroenterol Hepatol. 2016; 14: 1420-1425.</mixed-citation><mixed-citation xml:lang="en">Reddy K. M., Chang J. I., Shi J. M. et al. Risk of gastric cancer among patients with intestinal metaplasia of the stomach in a US integrated health care system // Clin Gastroenterol Hepatol. 2016; 14: 1420-1425.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lahner E., Esposito G., Pilozzi E. et al. Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up // Scand J Gastroenterol. 2015; 50: 856-865.</mixed-citation><mixed-citation xml:lang="en">Lahner E., Esposito G., Pilozzi E. et al. Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up // Scand J Gastroenterol. 2015; 50: 856-865.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Y. K., Yu J. C., Kang W. M. et al. Significance of serum pepsinogens as a biomarker for gastric cancer and atrophic gastritis screening: a systematic review and meta-analysis // PLoS One. 2015; 10: e0142080.</mixed-citation><mixed-citation xml:lang="en">Huang Y. K., Yu J. C., Kang W. M. et al. Significance of serum pepsinogens as a biomarker for gastric cancer and atrophic gastritis screening: a systematic review and meta-analysis // PLoS One. 2015; 10: e0142080.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kitahara F., Kobayashi K., Sato T. et al. Accuracy of screening for gastric cancer using serum pepsinogen concentrations // Gut. 1999; 44: 693-697.</mixed-citation><mixed-citation xml:lang="en">Kitahara F., Kobayashi K., Sato T. et al. Accuracy of screening for gastric cancer using serum pepsinogen concentrations // Gut. 1999; 44: 693-697.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hsing A. W., Hansson L. E., McLaughlin J. K. et al. Pernicious anemia and subsequent cancer. A population-based cohort study // Cancer. 1993; 71: 745-750.</mixed-citation><mixed-citation xml:lang="en">Hsing A. W., Hansson L. E., McLaughlin J. K. et al. Pernicious anemia and subsequent cancer. A population-based cohort study // Cancer. 1993; 71: 745-750.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Brinton L. A., Gridley G., Hrubec Z. et al. Cancer risk following pernicious anaemia // Br J Cancer. 1989; 59: 810-813.</mixed-citation><mixed-citation xml:lang="en">Brinton L. A., Gridley G., Hrubec Z. et al. Cancer risk following pernicious anaemia // Br J Cancer. 1989; 59: 810-813.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Mera R. M., Bravo L. E., Camargo M. C. et al. Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial // Gut. 2018; 67: 1239-1246. Epub 24 июня 2017 г.</mixed-citation><mixed-citation xml:lang="en">Mera R. M., Bravo L. E., Camargo M. C. et al. Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial // Gut. 2018; 67: 1239-1246. Epub 24 июня 2017 г.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Сиотани A., Уэдо Н., Ииши Х. и др. Реэкспрессия sonic hedgehog и снижение CDX2 после эрадикации Helicobacter pylori до неполной кишечной метаплазии // International Journal of Cancer. 2007, vol. 121, нет. 6, p. 1182-1189. Просмотр в издателе, просмотр в Google Scholar, просмотр в Scopus.</mixed-citation><mixed-citation xml:lang="en">Сиотани A., Уэдо Н., Ииши Х. и др. Реэкспрессия sonic hedgehog и снижение CDX2 после эрадикации Helicobacter pylori до неполной кишечной метаплазии // International Journal of Cancer. 2007, vol. 121, нет. 6, p. 1182-1189. Просмотр в издателе, просмотр в Google Scholar, просмотр в Scopus.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Сиотани A., Уэдо Н., Ииши Х. и др. Прогностические факторы метахронного рака желудка у пациентов высокого риска после успешной эрадикации Helicobacter pylori. Пищеварение. 2008, т. 78, нет. 2-3, p. 113-119. Просмотр в издателе, просмотр в Google Scholar, просмотр в Scopus.</mixed-citation><mixed-citation xml:lang="en">Сиотани A., Уэдо Н., Ииши Х. и др. Прогностические факторы метахронного рака желудка у пациентов высокого риска после успешной эрадикации Helicobacter pylori. Пищеварение. 2008, т. 78, нет. 2-3, p. 113-119. Просмотр в издателе, просмотр в Google Scholar, просмотр в Scopus.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kamada T., Sato M., Tokutomi T. et al. Rebamipide improves chronic inflammation in the lesser curvature of the corpus after Helicobacter pylori eradication: a multicenter study // Biomed Res Int. 2015; 5: 865146-865148.</mixed-citation><mixed-citation xml:lang="en">Kamada T., Sato M., Tokutomi T. et al. Rebamipide improves chronic inflammation in the lesser curvature of the corpus after Helicobacter pylori eradication: a multicenter study // Biomed Res Int. 2015; 5: 865146-865148.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Han X., Jiang K., Wang B. et al. Effect of Rebamipide on the Premalignant Progression of Chronic Gastritis: A Randomized Controlled Study // Clin Drug Investig. 2015; 35 (10): 665-673.</mixed-citation><mixed-citation xml:lang="en">Han X., Jiang K., Wang B. et al. Effect of Rebamipide on the Premalignant Progression of Chronic Gastritis: A Randomized Controlled Study // Clin Drug Investig. 2015; 35 (10): 665-673.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Arakawa T., Kobayashi K., Yoshikawa T. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing // Dig Dis Sci. 1998; 43 (9): 5-13.</mixed-citation><mixed-citation xml:lang="en">Arakawa T., Kobayashi K., Yoshikawa T. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing // Dig Dis Sci. 1998; 43 (9): 5-13.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Xiong J., Lai S., Zhang P. Rebamipide plus proton pump inhibitor versus proton pump inhibitor alone in the treatment of endoscopic submucosal dissection-induced gastric ulcer: a meta-analysis of randomized controlled trials // Medicine (Baltimore). 2014; 93 (12): 64. DOI: 10.1097/MD.0000000000000064.</mixed-citation><mixed-citation xml:lang="en">Xiong J., Lai S., Zhang P. Rebamipide plus proton pump inhibitor versus proton pump inhibitor alone in the treatment of endoscopic submucosal dissection-induced gastric ulcer: a meta-analysis of randomized controlled trials // Medicine (Baltimore). 2014; 93 (12): 64. DOI: 10.1097/MD.0000000000000064.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Du Y., Li Z., Zhan X. Anti-inflammatory effects of rebamipide according to Helicobacter pylori status in patients with chronic erosive gastritis: a randomized sucralfate-controlled multicenter trial in China-STARS study // Dig Dis Sci. 2008; 11: 2886-2895. DOI: 10.1007/s10620-007-0180-z.</mixed-citation><mixed-citation xml:lang="en">Du Y., Li Z., Zhan X. Anti-inflammatory effects of rebamipide according to Helicobacter pylori status in patients with chronic erosive gastritis: a randomized sucralfate-controlled multicenter trial in China-STARS study // Dig Dis Sci. 2008; 11: 2886-2895. DOI: 10.1007/s10620-007-0180-z.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Terano A., Arakawa T. Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial // J Gastroenterol. 2007; 42 (8): 690-693.</mixed-citation><mixed-citation xml:lang="en">Terano A., Arakawa T. Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial // J Gastroenterol. 2007; 42 (8): 690-693.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Mizukami K., Murakami K. Aspirin-induced small bowel injuries and the preventive effect of rebamipide // World J Gastroenterol. 2011; 46: 5117-5122. DOI: 10.3748/wjg.v17.i46.5117.</mixed-citation><mixed-citation xml:lang="en">Mizukami K., Murakami K. Aspirin-induced small bowel injuries and the preventive effect of rebamipide // World J Gastroenterol. 2011; 46: 5117-5122. DOI: 10.3748/wjg.v17.i46.5117.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang S., Qing Q., Bai Y. Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis // Dig Dis Sci. 2013; 7: 1991-2000. DOI: 10.1007/s10620-013-2606-0.</mixed-citation><mixed-citation xml:lang="en">Zhang S., Qing Q., Bai Y. Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis // Dig Dis Sci. 2013; 7: 1991-2000. DOI: 10.1007/s10620-013-2606-0.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В. Т., Маев И. В., Лапина Т. Л., Шептулин А. А., Трухманов А. С., Баранская Е. К., Абдулхаков Р. А., Алексеева О. П., Алексеенко С. А., Дехнич Н. Н., Козлов Р. С., Кляритская И. Л., Корочанская Н. В., Курилович С. А., Осипенко М. Ф., Симаненков В. И., Ткачев А. В., Хлынов И. Б., Цуканов В. В. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению инфекции Helicobacter pylori у взрослых // Рос. журн. гастроэнтерол. гепатол. колопроктол. 2018; 28 (1), с. 56-70.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В. Т., Маев И. В., Лапина Т. Л., Шептулин А. А., Трухманов А. С., Баранская Е. К., Абдулхаков Р. А., Алексеева О. П., Алексеенко С. А., Дехнич Н. Н., Козлов Р. С., Кляритская И. Л., Корочанская Н. В., Курилович С. А., Осипенко М. Ф., Симаненков В. И., Ткачев А. В., Хлынов И. Б., Цуканов В. В. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению инфекции Helicobacter pylori у взрослых // Рос. журн. гастроэнтерол. гепатол. колопроктол. 2018; 28 (1), с. 56-70.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Nishizawa T., Nishizawa Y., Yahagi N., Kanai T., Takahashi M., Suzuki H. Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: a systematic review and meta-analysis // J Gastroenterol Hepatol. 2014; 29 (Suppl 4): 20-24. DOI: 10.1111/jgh.12769.</mixed-citation><mixed-citation xml:lang="en">Nishizawa T., Nishizawa Y., Yahagi N., Kanai T., Takahashi M., Suzuki H. Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: a systematic review and meta-analysis // J Gastroenterol Hepatol. 2014; 29 (Suppl 4): 20-24. DOI: 10.1111/jgh.12769.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
