lvrachЛечащий ВрачLechaschi Vrach1560-51752687-118110.26295/OS.2020.98.43.008lvrach-219Research ArticleСтатьиСовременные данные о видах иммунного ответаCurrent condition of immune response typesСизовД. А.SizovD. A.

Хабаровск

Khabarovsk

noemail@neicon.ruРукинаН. Ю.RukinaN. Yu.

кандидат медицинских наук,

Хабаровск

Khabarovsk

ФГБОУ ВО ДВГМУ МЗ РФРоссияFar Eastern National Medical UniversityRussian Federation2020230620210113539Copyright © Сизов Д.А., Рукина Н.Ю., 20212021Сизов Д.А., Рукина Н.Ю.Sizov D.A., Rukina N.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.lvrach.ru/jour/article/view/219

В статье раскрыто современное определение иммунного ответа. Филогенез иммунитета составляет единую систему и является неотделимой частью развития многоклеточных микроорганизмов. Возникновение многоклеточных организмов способствовало формированию обособленного сообщества клеток, которые бы отвечали за поддержание гомеостаза внутренней среды организма. Взаимодействие данных клеток явилось прообразом современного иммунитета, а видом регуляции постоянства внутренней среды стал иммунный ответ. Роль иммунного ответа в организме заключается в следующем: поиск и элиминация чужеродных частиц, как проникающих экзогенно (возбудители инфекционных заболеваний), так и эндогенно образованных (инфицированные вирусами клетки, опухолевые клетки). Определена роль врожденного и приобретенного иммунного ответа. Особый акцент сделан на патоген-распознающие рецепторы, на их различные виды. Раскрыто понятие патоген-распознающих рецепторов, показаны их взаимодействие и активация при различных видах патогенов. Охарактеризованы современные представления об интерлейкинах и факторах транскрипции.

The article discloses a modern definition of the immune response. The phylogenesis of immunity constitutes a single system and is an integral part of the development of multicellular microorganisms. The emergence of multicellular organisms contributed to the formation of a separate community of cells that would be responsible for maintaining homeostasis of the internal environment of the body. The interaction of these cells was a prototype of modern immunity, and the immune response became a form of regulation of the constancy of the internal environment. The role of the immune response in the body is as follows: the search and elimination of foreign particles, both exogenously penetrating (pathogens of infectious diseases) and endogenously formed (cells infected with viruses, tumor cells). The role of the innate and acquired immune response is determined. Particular emphasis is placed on the pathogen recognizing receptors, on their various types. The concept of a pathogen of recognizing receptors is disclosed, their interaction and activation is shown for various types of pathogens. Modern perceptions of interleukins and transcription factors are characterized. 

ВакцинопрофилактикаВрожденный иммунитетИммунная системаИнтерлейкиныИнфекцииЛимфоцитыОрганеллыПатоген-распознающие рецепторыПриобретенный иммунитетТ-хелперыФакторы транскрипцииХемокиныinnate immunityacquired immunitypathogen recognition receptorschemokinesinterleukinslymphocyteT-helpersimmune systemtranscription factorsorganellesReferencesHuber J. P., Farrar D. J. Regulation of effector and memory T-cell functions by type I interferon // Immunology. 2011; 132: 466-474.Huber J. P., Farrar D. J. Regulation of effector and memory T-cell functions by type I interferon // Immunology. 2011; 132: 466-474.Dolasia K., et al. TLRs/NLRs: Shaping the landscape of host immunity // Int. Rev. Immunol. 2018; 37: 3-19.Dolasia K., et al. TLRs/NLRs: Shaping the landscape of host immunity // Int. Rev. Immunol. 2018; 37: 3-19.Lotze M. T., Tracey K. J. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal // Nat Rev Immunol. 2005; 5: 331-342.Lotze M. T., Tracey K. J. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal // Nat Rev Immunol. 2005; 5: 331-342.Andersson U., Tracey K. J. HMGB1 is a therapeutic target for sterile inflammation and infection // Annu Rev Immunol. 2011; 29: 139-162.Andersson U., Tracey K. J. HMGB1 is a therapeutic target for sterile inflammation and infection // Annu Rev Immunol. 2011; 29: 139-162.Venereau E., et al. HMGB1 as biomarker and drug target // Pharmacol Res. 2016; 111: 534-544.Venereau E., et al. HMGB1 as biomarker and drug target // Pharmacol Res. 2016; 111: 534-544.Schiraldi M., et al. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 // J Exp Med. 2012; 209: 551-563.Schiraldi M., et al. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 // J Exp Med. 2012; 209: 551-563.Schaefer L. Complexity of danger: the diverse nature of damage-associated molecular patterns // J Biol Chem. 2014; 289: 35237-35245.Schaefer L. Complexity of danger: the diverse nature of damage-associated molecular patterns // J Biol Chem. 2014; 289: 35237-35245.Jin H. S., et al. Mitochondrial control of innate immunity and inflammation // Immune Netw. 2017; 17: 77-88.Jin H. S., et al. Mitochondrial control of innate immunity and inflammation // Immune Netw. 2017; 17: 77-88.Santoni G., et al. Danger - and pathogen-associated molecular patterns recognition by pattern recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. J Neuro inflammation. 2015; 12: 21.Santoni G., et al. Danger - and pathogen-associated molecular patterns recognition by pattern recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. J Neuro inflammation. 2015; 12: 21.Boyapati R. K., et al. Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications // Muc. Immunol. 2016; 9 (3): 567-582.Boyapati R. K., et al. Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications // Muc. Immunol. 2016; 9 (3): 567-582.Beutler B. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases // Immunol. 2009; 227 (1): 248-263.Beutler B. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases // Immunol. 2009; 227 (1): 248-263.Goubau D., Deddouche S., Reis e Sousa C. Cytosolic sensing of viruses // Immunity. 2013; 38: 855-869.Goubau D., Deddouche S., Reis e Sousa C. Cytosolic sensing of viruses // Immunity. 2013; 38: 855-869.Joosten L. A., et al. Toll-like receptors and chronic inflammation in rheumatic diseases: New developments // Nat. Rev. Rheumatol. 2016; 12: 344-357.Joosten L. A., et al. Toll-like receptors and chronic inflammation in rheumatic diseases: New developments // Nat. Rev. Rheumatol. 2016; 12: 344-357.Zakeri A, Russo M. Dual Role of Toll-like Receptors in Human and Experimental Asthma Models // Front. Immunol. 2018; 9: 1027.Zakeri A, Russo M. Dual Role of Toll-like Receptors in Human and Experimental Asthma Models // Front. Immunol. 2018; 9: 1027.Barber G. N. Cytoplasmic DNA innate immune pathways // Immunol. 2011; 243 (1): 99-108.Barber G. N. Cytoplasmic DNA innate immune pathways // Immunol. 2011; 243 (1): 99-108.Barber G. N. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses // Curr. Opin. Immunol. 2011; 23 (1): 10-20.Barber G. N. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses // Curr. Opin. Immunol. 2011; 23 (1): 10-20.Xie L., et al. Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI) // Dev. Comp. Immunol. 2010; 34 (3): 293-299.Xie L., et al. Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI) // Dev. Comp. Immunol. 2010; 34 (3): 293-299.Игнатов П. Е. Иммунитет и инфекция. М.: Время, 2002. 352 с. @@Ignatov P. Ye. Immunitet i infektsiya. (Immunity and infection.) M.: Vremya, 2002. 352.Игнатов П. Е. Иммунитет и инфекция. М.: Время, 2002. 352 с. @@Ignatov P. Ye. Immunitet i infektsiya. (Immunity and infection.) M.: Vremya, 2002. 352.Murphy K., et al. Janeway's Immunobiology, 9th Edition. New York, NY: Garland Science, 2016. P. 29.Murphy K., et al. Janeway's Immunobiology, 9th Edition. New York, NY: Garland Science, 2016. P. 29.Gu J., et al. Human cd39hi regulatory T cells present stronger stability and function under inflammatory conditions // Cell Mol Immunol. 2017; 14: 521-528.Gu J., et al. Human cd39hi regulatory T cells present stronger stability and function under inflammatory conditions // Cell Mol Immunol. 2017; 14: 521-528.Van Gool F. et al. A mutation in the transcription factor Foxp3 drives T helper 2 effector function in regulatory T cells // Immunity. 2019; 50: 362-377.Van Gool F. et al. A mutation in the transcription factor Foxp3 drives T helper 2 effector function in regulatory T cells // Immunity. 2019; 50: 362-377.Van Nimwegen E. Scaling laws in the functional content of genomes // Trends Genet journal. 2003; 19 (9): 479-484.Van Nimwegen E. Scaling laws in the functional content of genomes // Trends Genet journal. 2003; 19 (9): 479-484.Zaret K. S., Mango S. E. Pioneer transcription factors, chromatin dynamics, and cell fate control // Curr. Opin. Genet. Dev. 2016; 37: 76-81.Zaret K. S., Mango S. E. Pioneer transcription factors, chromatin dynamics, and cell fate control // Curr. Opin. Genet. Dev. 2016; 37: 76-81.Huang W., et al. ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells // Nat. Commun. 2017; 8: 15871.Huang W., et al. ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells // Nat. Commun. 2017; 8: 15871.Smith E. L., et al. Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation // Immunology. 2006; 119: 203-211.Smith E. L., et al. Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation // Immunology. 2006; 119: 203-211.Хаитов Р. М. Иммунология. М.: ГЭОТАР-Медиа, 2018. 496 с. @@Khaitov R. M. Immunologiya. (Immunology.) M.: GEOTAR-Media, 2018. P. 496.Хаитов Р. М. Иммунология. М.: ГЭОТАР-Медиа, 2018. 496 с. @@Khaitov R. M. Immunologiya. (Immunology.) M.: GEOTAR-Media, 2018. P. 496.Iwamoto T., et al. Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients // FEBS J. 2008; 275 (18): 4448-4455.Iwamoto T., et al. Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients // FEBS J. 2008; 275 (18): 4448-4455.Trifari S., et al. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells // Nat Immunol. 2009; 10: 864-871.Trifari S., et al. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells // Nat Immunol. 2009; 10: 864-871.Lee A. Y., et al. CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil? // Front Immunol. 2013; 4: 194.Lee A. Y., et al. CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil? // Front Immunol. 2013; 4: 194.Dinarello C. Historical insights into cytokines // European Journal of Immunology. 2007; 37 (1): 34-45.Dinarello C. Historical insights into cytokines // European Journal of Immunology. 2007; 37 (1): 34-45.Su D. L., et al. Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE // Journal of Biomedicine and Biotechnology. 2012; vol. 2012.Su D. L., et al. Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE // Journal of Biomedicine and Biotechnology. 2012; vol. 2012.Eberl G. Immunity by equilibrium // Nat. Rev. Immunol. 16, 524-532.Eberl G. Immunity by equilibrium // Nat. Rev. Immunol. 16, 524-532.Hasegawa H., et al. Expanding diversity in molecular structures and functions of the IL-6/IL-12 heterodimeric cytokine family // Front. Immunol. 2016; 7: 479.Hasegawa H., et al. Expanding diversity in molecular structures and functions of the IL-6/IL-12 heterodimeric cytokine family // Front. Immunol. 2016; 7: 479.Cavaillon J. M. Pro- versus anti-inflammatory cytokines: myth or reality // Cellular and Molecular Biology. 2001; 47 (4): 695-702.Cavaillon J. M. Pro- versus anti-inflammatory cytokines: myth or reality // Cellular and Molecular Biology. 2001; 47 (4): 695-702.Tengvall S., et al. Interleukin-26: An Emerging Player in Host Defense and Inflammation // Journal of Innate Immunity. 2016; 8 (1): 15-22.Tengvall S., et al. Interleukin-26: An Emerging Player in Host Defense and Inflammation // Journal of Innate Immunity. 2016; 8 (1): 15-22.Iwasaki A., Pillai P. S. Innate immunity to influenza virus infection // Nature Reviews Immunology. 2014; 14 (5): 315-328.Iwasaki A., Pillai P. S. Innate immunity to influenza virus infection // Nature Reviews Immunology. 2014; 14 (5): 315-328.

The authors declare that there are no conflicts of interest present.