lvrachЛечащий ВрачLechaschi Vrach1560-51752687-118110.26295/OS.2020.78.43.006lvrach-188Research ArticleСтатьиИнтестинальный белок, связывающий жирные кислоты, в диагностике некротизирующего энтероколита у детейInterstitial protein that binds fatty acids in the diagnosis of necrotizing enterocolitis in childrenБавыкинаИ. А.BavykinaI. A.

Voronezh

i-bavikina@yandex.ruБердниковА. А.BerdnikovA. A.

Voronezh

noemail@neicon.ruФГБОУ ВО ВГМУ им. Н. Н. Бурденко МЗ РФРоссияThe State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian FederationRussian FederationБУЗ ВО ВОДКБ № 1РоссияBudgetary healthcare institution of the Voronezh region «Voronezh Regional Children’s Clinical Hospital No. 1»Russian Federation202023062021093133Copyright © Бавыкина И.А., Бердников А.А., 20212021Бавыкина И.А., Бердников А.А.Bavykina I.A., Berdnikov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.lvrach.ru/jour/article/view/188

Некротизирующий энтероколит является многофакторной патологией с неуточненным патогенезом. Эти факторы в значительной степени усложняют дифференциальную диагностику, что оказывает влияние на своевременную терапию и прогноз заболевания. Интестинальныйбелок, связывающий жирные кислоты, является специфическим маркером повреждения энтероцитов, однако до настоящего дня не уточнены его референсные значения. Данный маркер зарекомендовал себя при таких патологиях, как целиакия, гнойные заболевания и травмы живота, при проведении абдоминальных операций и прочих патологиях, сопровождающихся изменениями морфологической и гистологической картины в кишечнике. В статье приведены современные литературные данные о диагностической ценности определения уровня белка, связывающего жирные кислоты, как маркера повреждения энтероцитов при некротическом энтероколите у детей. Показано значение как при проведении дифференциальной диагностики, так и прогностическое значение повышения концентрации маркера в крови или моче пациентов.

Necrotizing enterocolitis is a multifactorial pathology with an unspecified pathogenesis. These factors significantly complicate the differential diagnosis, which affects timely therapy and prognosis of the disease. The interstitial protein that binds fatty acids is a specific marker of enterocyte damage; however, the reference values have not yet been clarified. This marker has proven itself in pathologies such as celiac disease, purulent diseases and abdominal trauma, during abdominal operations and other pathologies accompanied by changes in the morphological and histological picture in the intestine. The article presents modern literature data on the diagnostic value of determining the level of protein that binds fatty acids as a marker of damage to enterocytes in necrotizing enterocolitis in children. The value is shown both for differential diagnostics and the prognostic value of an increase in the concentration of the marker in the blood or urine of patients. 

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The authors declare that there are no conflicts of interest present.