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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26295/OS.2020.87.84.008</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-174</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Перспективы применения фитотерапии в лечении пациентов с неалкогольной жировой болезнью печени</article-title><trans-title-group xml:lang="en"><trans-title>Prospects for the use of herbal medicine in the treatment of patients with non-alcoholic fatty liver disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмедов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="en"><p>Doctor of Medicine, Professor,</p><p>Omsk</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меликов</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Melikov</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="en"><p>Omsk</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО ОмГМУ МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education, Omsk State Medical University of the Healthcare Ministry of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>8</issue><fpage>54</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ахмедов В.А., Меликов Т.И., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Ахмедов В.А., Меликов Т.И.</copyright-holder><copyright-holder xml:lang="en">Akhmedov V.A., Melikov T.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/174">https://journal.lvrach.ru/jour/article/view/174</self-uri><abstract><p>Модификация образа жизни, которая включает в себя соблюдение диеты и физическую активность, а также снижение веса, остается первой линией лечения неалкогольной жировой болезни печени (НАЖБП). Тем не менее из-за плохой приверженности к данному виду лечения имеется интерес к выявлению новых потенциально эффективных терапевтических агентов для лечения и/или профилактики прогрессирования НАЖБП. В связи с потенциальными неблагоприятными эффектами традиционной медицинской терапии особое внимание уделяется изучению дополнительных методов лечения, таких как фитотерапия и использование в лечении растительных продуктов в виде сухих веществ или их экстрактов.Те пациенты, которые не достигают целей с помощью классической терапии, являются потенциальными кандидатами на получение травяных нутрицевтиков.Однако следует учитывать, что нутрицевтики продаются в виде смесей различных соединений, поэтому их назначение не всегда легко для врача. Также необходимо оценить стоимость, отдаленные последствия и потенциальный риск лекарственного взаимодействия для пациентов. При использовании очищенных фитохимических веществ вышеупомянутые проблемы значительно упрощаются по сравнению с растительными экстрактами. Несмотря на то, что в настоящее время проводится несколько клинических испытаний для оценки терапевтического эффекта нутрицевтиков и растительных продуктов, предполагается, что ученые больше внимания будут уделять оценке эффективности растительных терапевтических средств в будущем, путем проведения более крупных рандомизированных клинических испытаний и тщательной оценки их результатов.</p></abstract><trans-abstract xml:lang="en"><p>Lifestyle modification, which includes the following: a healthy diet and physical activity, along with weight reduction, remains the first line of treatment for non-alcoholic fatty liver disease (NAFLD). However, due to the poor adherence to this type of treatment, especially for long-term weight loss diets, some of which may have harmful effects on the liver, there is significant interest in identifying therapeutic agents for the treatment and/or prevention of NAFLD progression. Due to potential adverse effects of conventional medical therapies, the focus has been directed to studying complementary therapies that are both natural and safe, such as herbal medicine and functional foods as dry materials or their extracts.</p><p>Those patients who fail to achieve goals with classical therapy are potential candidates for herbal nutraceuticals.</p><p>However, it should be borne in mind that nutraceuticals are sold in the form of mixtures of various compounds, so their appointment is not always easy for the doctor. It is also necessary to assess the cost, long-term effects and potential risk of drug interactions for patients. When using purified phytochemicals, the above problems are greatly simplified compared to plant extracts. Although several clinical trials are currently underway to evaluate the therapeutic effect of nutraceuticals and plant products, it is anticipated that scientists will pay more attention to assessing the efficacy of herbal therapeutic agents in the future by conducting larger randomized clinical trials and carefully evaluating their results. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Гепатология</kwd><kwd>Модификация образа жизни</kwd><kwd>Неалкогольная жировая болезнь печени</kwd><kwd>Растительные биологически активные вещества</kwd><kwd>Терапевтическое средство</kwd><kwd>Терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>non-alcoholic fatty liver disease</kwd><kwd>herbal bioactives</kwd><kwd>lifestyle modification</kwd><kwd>therapeutic agent</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dowman J. K., Tomlinson J., Newsome P. 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