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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2025.28.9.001</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1459</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕДИАТРИЯ. НЕОНАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PEDIATRICS. NEONATOLOGY</subject></subj-group></article-categories><title-group><article-title>Гастропатии у детей, индуцированные НПВП: случай язвенного кровотечения у ребенка на фоне приема кеторолака</article-title><trans-title-group xml:lang="en"><trans-title>Gastropathies in children induced by NSAIDs: a case of ulcerative bleeding in a child taking ketorolac</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5115-6185</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шумейко</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Shumeyko</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шумейко Наталья Константиновна, к.м.н., доцент кафедры педиатрии</p><p>127006, Москва, ул. Долгоруковская, 4</p></bio><bio xml:lang="en"><p>Natalia K. Shumeyko, Cand. of Sci. (Med.), Associate Professor of the Department of Pediatrics</p><p>4 Dolgorukovskaya str., Moscow, 127006</p></bio><email xlink:type="simple">shumnatalia@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3426-3426</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaytseva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зайцева Ольга Витальевна, д.м.н., профессор, заведующая кафедрой педиатрии</p><p>127006, Москва, ул. Долгоруковская, 4</p></bio><bio xml:lang="en"><p>Olga V. Zaytseva, Dr. of Sci. (Med.), Professor, Head of the Department of Pediatrics</p><p>4 Dolgorukovskaya str., Moscow, 127006</p></bio><email xlink:type="simple">olga6505963@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6006-7846</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Локшина</surname><given-names>Э. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Lokshina</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Локшина Эвелина Эдуардовна, к.м.н., профессор кафедры педиатрии</p><p>127006, Москва, ул. Долгоруковская, 4</p></bio><bio xml:lang="en"><p>Evelina E. Lokshina, Cand. of Sci. (Med.), Professor of the Department of Pediatrics</p><p>4 Dolgorukovskaya str., Moscow, 127006</p></bio><email xlink:type="simple">elokshina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6278-9508</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Серебровская</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Serebrovskaya</surname><given-names>N. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Серебровская Надежда Борисовна, к.м.н., доцент кафедры педиатрии</p><p>127006, Москва, ул. Долгоруковская, 4</p></bio><bio xml:lang="en"><p>Nadezhda B. Serebrovskaya, Cand. of Sci. (Med.), Associate Professor of the Department of Pediatrics</p><p>4 Dolgorukovskaya str., Moscow, 127006</p></bio><email xlink:type="simple">nserebrovskaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9163-2390</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рычкова</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Rychkova</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рычкова Татьяна Ивановна, к.м.н., доцент кафедры педиатрии</p><p>127006, Москва, ул. Долгоруковская, 4</p></bio><bio xml:lang="en"><p>Tatiana I. Rychkova, Cand. of Sci. (Med.), Associate Professor of the Department of Pediatrics</p><p>4 Dolgorukovskaya str., Moscow, 127006</p></bio><email xlink:type="simple">info@rosunimed.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>9</issue><fpage>8</fpage><lpage>13</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шумейко Н.К., Зайцева О.В., Локшина Э.Э., Серебровская Н.Б., Рычкова Т.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шумейко Н.К., Зайцева О.В., Локшина Э.Э., Серебровская Н.Б., Рычкова Т.И.</copyright-holder><copyright-holder xml:lang="en">Shumeyko N.K., Zaytseva O.V., Lokshina E.E., Serebrovskaya N.B., Rychkova T.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1459">https://journal.lvrach.ru/jour/article/view/1459</self-uri><abstract><sec><title>Введение</title><p>Введение. Термин «НПВП-гастропатии» был предложен в 1986 г. для того, чтобы отличить специфическое поражение слизистой оболочки желудка, возникающее при длительном употреблении нестероидных противовоспалительных препаратов (НПВП), от классической язвенной болезни. Широкое применение нестероидных противовоспалительных препаратов, с одной стороны, и необходимость их длительного или постоянного приема – с другой, обусловливают распространение НПВП-гастропатий. В настоящее время отмечается тенденция к увеличению потребления нестероидных противовоспалительных препаратов в 2-3 раза каждые 10 лет. Ежегодно число принимающих нестероидные противовоспалительные препараты составляет более 300 млн человек, при этом лишь 1/3 из них делают это по назначению врача.</p></sec><sec><title>Цель работы</title><p>Цель работы. Статья посвящена одной из актуальных проблем детской гастроэнтерологии – язвенной болезни желудка и двенадцатиперстной кишки и осложнениям в виде желудочно-кишечных кровотечений.</p></sec><sec><title>Результаты</title><p>Результаты. Приведены данные по вопросам патогенеза, диагностики и лечения язвенных кровотечений у детей. Отмечается, что диагностика язвенных кровотечений базируется на совокупности клинических проявлений, данных лабораторных и инструментальных исследований. В статье приведены сведения о распространенности, значимых факторах в развитии заболевания; данные исследований, выявляющих связь между приемом лекарственных препаратов, в основном нестероидных противовоспалительных, и риском возникновения гастропатии с язвенным кровотечением, индуцированной нестероидными противовоспалительными препаратами. В статье показано, как они влияют на течение язвенной болезни желудка и двенадцатиперстной кишки. Приводятся данные о возможности возникновения язвенного кровотечения на фоне приема данных лекарственных средств. В качестве демонстрации приведены данные собственного наблюдения авторов. В клиническом примере описан случай язвенного кровотечения у подростка, бесконтрольно принимающего нестероидные противовоспалительные препараты.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The term "NSAID-induced gastropathy" was proposed in 1986 to distinguish specific damage to the gastric mucosa caused by prolonged use of nonsteroidal anti-inflammatory drugs from classic peptic ulcer disease. The widespread use of nonsteroidal antiinflammatory drugs (NSAIDs), on the one hand, and the need for their prolonged or continuous use, on the other, contribute to the spread of NSAID-induced gastropathy. Currently, there is a trend toward a 2-3-fold increase in the consumption of nonsteroidal antiinflammatory drugs every 10 years. Each year, more than 300 million people take nonsteroidal anti-inflammatory drugs, with only 1/3 of them doing so as prescribed by a doctor.</p></sec><sec><title>Objective</title><p>Objective. The article is devoted to one of the urgent problems of pediatric gastroenterology – peptic ulcer of the stomach and duodenum and complications in the form of gastrointestinal bleeding.</p></sec><sec><title>Results</title><p>Results. Data on the pathogenesis, diagnosis, and treatment of ulcerative bleeding in children are presented. It is noted that the diagnosis of ulcerative bleeding is based on a combination of clinical manifestations, laboratory and instrumental studies. The article provides information on the prevalence, significant factors in the development of the disease, and research data showing a link between taking medications, mainly nonsteroidal anti-inflammatory drugs, and the risk of NSAID-induced gastropathy and ulcerative bleeding. The article shows how nonsteroidal anti-inflammatory drugs affect the course of peptic ulcer of the stomach and duodenum. Data on the possibility of ulcerative bleeding while taking nonsteroidal anti-inflammatory drugs are presented. The authors' own observations are presented as a demonstration. A clinical example describes a case of ulcerative bleeding in a teenager taking nonsteroidal anti-inflammatory drugs uncontrollably.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>язвенная болезнь желудка и двенадцатиперстной кишки</kwd><kwd>язвенное кровотечение</kwd><kwd>нестероидные противовоспалительные препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>peptic ulcer of the stomach and duodenum</kwd><kwd>ulcerative bleeding</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Волевач Л. В., Нафикова А. Ш., Габбасова Л. В., Сарсенбаева А. С. Язвенная болезнь. Факторы, влияющие на качество жизни: Монография. М-во образования и науки РФ, БГМУ. Тамбов: Консалтинговая компания Юком, 2019. 100 с. 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