<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name>ООО «Издательство "Открытые системы"»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2025.28.5.003</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1411</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Синдром Гайе — Вернике при беременности: клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Gayet — Wernicke syndrome in pregnancy: a clinical case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0948-3964</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каменских</surname><given-names>Г. B.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamenskikh</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каменских Гаянэ Валериевна, к.м.н., акушер-гинеколог, Краевая клиническая больница № 2, Перинатальный центр </p><p>350001, Краснодар, ул. Таманская, 130</p></bio><bio xml:lang="en"><p>Gayane V. Kamenskikh, Cand. of Sci. (Med.), obstetrician-gynecologist, Regional Clinical Hospital No. 2, Perinatal Center</p><p>130 Tamanskaya St., Krasnodar, 350001</p></bio><email xlink:type="simple">gaene@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Березнёв</surname><given-names>В. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Bereznev</surname><given-names>V. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Березнёв Василий Константинович, ординатор кафедры акушерства, гинекологии и перинатологии</p><p>Краснодар, ул. Митрофана Седина, 4</p></bio><bio xml:lang="en"><p>Vasiliy K. Bereznyov, Resident of the Department of Obstetrics, Gynecology and Perinatology</p><p>4 Mitrofana Sedina str., Krasnodar, 350063</p></bio><email xlink:type="simple">vasilii_bereznev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чирва</surname><given-names>Ж. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chirva</surname><given-names>Zh. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чирва Жанна Александровна, невролог высшей категории, Краевая клиническая больница № 2, неврологический  центр  поликлиники специализированного курсового амбулаторного лечения</p><p>350012, Краснодар, ул. Красных партизан 6, корп. 2</p></bio><bio xml:lang="en"><p>Zhanna А. Chirva, Neurologist of the Highest Category, Regional Clinical Hospital No. 2, Neurological Center of the polyclinic for specialized outpatient treatment</p><p>6 bld.2 Krasnykh Partizan str., Krasnodar, 350012</p></bio><email xlink:type="simple">z_chirva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Краевая клиническая больница № 2</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Regional Hospital No. 2</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кубанский  государственный  медицинский  университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>05</month><year>2025</year></pub-date><volume>0</volume><issue>5</issue><fpage>22</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каменских Г.B., Березнёв В.К., Чирва Ж.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Каменских Г.B., Березнёв В.К., Чирва Ж.А.</copyright-holder><copyright-holder xml:lang="en">Kamenskikh G.V., Bereznev V.K., Chirva Z.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1411">https://journal.lvrach.ru/jour/article/view/1411</self-uri><abstract><sec><title>Введение</title><p>Введение. Синдром Гайе – Вернике развивается в результате дефицита витамина В1, что чаще всего встречается у людей, страдающих алкоголизмом или мальабсорбцией вследствие заболеваний кишечника или бариатрических операций.</p><p>При беременности данное состояние может развиваться вследствие длительной неукротимой рвоты, из-за чего нарушаются баланс веществ в организме и всасывание питательных веществ в кишечнике. Однако это состояние встречается достаточно редко, а проявления в виде полинейропатии и отсутствия классической триады могут представлять определенную трудность в дифференциальной диагностике и своевременном назначении терапии.</p></sec><sec><title>Результаты</title><p>Результаты. В данной статье представлен клинический случай ведения беременной в 38 недель с клинической картиной синдрома Гайе – Вернике вследствие перенесенной в тяжелой форме рвоты беременных в первом триместре и метаболических нарушений в третьем.</p></sec><sec><title>Заключение</title><p>Заключение. Поскольку синдром Гайе – Вернике – относительно редкое заболевание, акушеры-гинекологи, офтальмологи, терапевты и неврологи, которые наблюдают беременных, должны внимательно относиться к появлению жалоб пациенток на нарушение памяти, слабость, онемение и ощущение слабости в конечностях, нарушение координации. Конечно, такие жалобы нередки у беременных, но надо всегда помнить о том, что они могут быть ранними признаками синдрома Гайе – Вернике.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Gayet – Wernicke syndrome develops as a result of vitamin B1 deficiency, which is most often found in people suffering from alcoholism or malabsorption due to intestinal diseases or bariatric surgeries. During pregnancy, this condition can develop as a result of prolonged uncontrollable vomiting, which disrupts the balance of substances in the body and the absorption of nutrients in the intestine. However, this condition is quite rare, and manifestations in the form of polyneuropathy and the absence of the classical triad can present a certain difficulty in differential diagnosis and timely administration of therapy.</p></sec><sec><title>Results</title><p>Results. This article presents a clinical case of a pregnant woman at 38 weeks with a clinical picture of Gayet – Wernicke syndrome due to severe vomiting of pregnancy in the first trimester and metabolic disorders in the third.</p></sec><sec><title>Conclusion</title><p>Conclusion. Since Gayet – Wernicke syndrome is a relatively rare disease, obstetricians-gynecologists, ophthalmologists, therapists and neurologists who observe pregnant women should pay close attention to the appearance of patient complaints about memory impairment, weakness, numbness in the limbs and feelings of weakness in the limbs, and impaired coordination. Of course, such complaints are not uncommon in pregnant women, but we must always remember that there is a possibility that they may be early signs of Gayet – Wernicke syndrome.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>синдром Гайе – Вернике</kwd><kwd>клинический случай</kwd><kwd>дефицит В1</kwd><kwd>дефицит тиамина</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>Gayet – Wernicke syndrome</kwd><kwd>clinical case</kwd><kwd>B1 deficiency</kwd><kwd>thiamine deficiency</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Weisshof R., Chermesh I. Micronutrient deficiencies in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2015; 18 (6): 576-581. DOI: 10.1097/MCO.0000000000000226. PMID: 26418823.</mixed-citation><mixed-citation xml:lang="en">Weisshof R., Chermesh I. Micronutrient deficiencies in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2015; 18 (6): 576-581. DOI:  10.1097/MCO.0000000000000226. PMID: 26418823.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dervaux A., Laqueille X. Le traitement par thiamine (vitamine B1) dans l’alcoolodépendance [Thiamine (vitamin B1) treatment in patients with alcohol dependence]. Presse Med. 2017; 46 (2 Pt 1): 165-171. French. DOI: 10.1016/j.lpm.2016.07.025. Epub 2016 Nov 3. PMID:27818067.</mixed-citation><mixed-citation xml:lang="en">Dervaux A., Laqueille X. Le traitement par thiamine (vitamine B1) dans l’alcoolodépendance [Thiamine (vitamin B1) treatment in patients with alcohol dependence]. Presse Med. 2017; 46 (2 Pt 1): 165-171. French. DOI: 10.1016/j.lpm.2016.07.025. Epub 2016 Nov 3. PMID:27818067.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bahardoust M., Eghbali F., Shahmiri S. S., Alijanpour A., Yarigholi F., Valizadeh R., Madankan A., Pouraskari A. B., Ashtarinezhad B., Farokhi H., Sarafraz H., Khanafshar E. B1 Vitamin Deficiency After Bariatric Surgery, Prevalence, and Symptoms: a Systematic Review and Metaanalysis. Obes Surg. 2022; 32 (9): 3104-3112. DOI: 10.1007/s11695-022-06178-7. Epub 2022 Jul 1. PMID: 35776243.</mixed-citation><mixed-citation xml:lang="en">Bahardoust M., Eghbali F., Shahmiri S. S., Alijanpour A., Yarigholi F., Valizadeh R.,  Madankan A., Pouraskari A. B., Ashtarinezhad B., Farokhi H., Sarafraz H., Khanafshar E. B1 Vitamin Deficiency After Bariatric Surgery, Prevalence, and Symptoms: a Systematic Review and Metaanalysis. Obes Surg. 2022; 32 (9): 3104-3112. DOI: 10.1007/s11695-022-06178-7. Epub 2022  Jul 1. PMID: 35776243.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mrowicka M., Mrowicki J., Dragan G., Majsterek I. The importance of thiamine (vitamin B1) in humans. Biosci Rep. 2023; 43 (10): BSR20230374. DOI: 10.1042/BSR20230374. PMID: 37389565; PMCID: PMC10568373.</mixed-citation><mixed-citation xml:lang="en">Mrowicka M., Mrowicki J., Dragan G., Majsterek I. The importance of thiamine (vitamin B1) in humans. Biosci Rep. 2023; 43 (10): BSR20230374. DOI: 10.1042/BSR20230374. PMID: 37389565; PMCID: PMC10568373.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hazell A. S. Stem Cell Therapy and Thiamine Deficiency-Induced Brain Damage. Neurochem Res. 2024; 49 (6): 1450-1467. DOI: 10.1007/s11064-024-04137-5. Epub 2024 May 9. PMID: 38720090.</mixed-citation><mixed-citation xml:lang="en">Hazell A. S. Stem Cell Therapy and Thiamine Deficiency-Induced Brain Damage. Neurochem Res. 2024; 49 (6): 1450-1467.  DOI: 10.1007/s11064-024-04137-5. Epub 2024 May 9. PMID: 38720090.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Frank L. L. Thiamin in Clinical Practice. JPEN J Parenter Enteral Nutr. 2015; 39 (5): 503-520. DOI: 10.1177/0148607114565245. Epub 2015 Jan 6. PMID: 25564426.</mixed-citation><mixed-citation xml:lang="en">Frank L. L. Thiamin in Clinical Practice. JPEN J Parenter Enteral Nutr. 2015; 39 (5): 503-520. DOI: 10.1177/0148607114565245. Epub 2015 Jan 6. PMID: 25564426.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rane M. A., Boorugu H. K., Ravishankar U., Tarakeswari S., Vadlamani H., Anand H. Wernicke's encephalopathy in women with hyperemesis gravidarum – Case series and literature review. Trop Doct. 2022; 52 (1): 98-100. DOI: 10.1177/00494755211014396. Epub 2021 Jun 24. PMID: 34167385.</mixed-citation><mixed-citation xml:lang="en">Rane M. A., Boorugu H. K., Ravishankar U., Tarakeswari S., Vadlamani H., Anand H. Wernicke's encephalopathy in women with hyperemesis gravidarum – Case series and literature review. Trop Doct. 2022; 52 (1): 98-100. DOI: 10.1177/00494755211014396. Epub 2021 Jun 24. PMID: 34167385.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Oudman E., Wijnia J. W., Oey M. J., van Dam M. J., Postma A. Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review. Psychiatry Clin Neurosci. 2018; 72 (10): 774-779. DOI: 10.1111/pcn.12735. Epub 2018 Jul 31. PMID: 29984541.</mixed-citation><mixed-citation xml:lang="en">Oudman E., Wijnia J. W., Oey M. J., van Dam M. J., Postma A. Preventing Wernicke's encephalopathy  in anorexia nervosa: A systematic review. Psychiatry Clin Neurosci. 2018; 72 (10): 774-779. DOI: 10.1111/pcn.12735. Epub 2018 Jul 31. PMID: 29984541.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wedisinghe L., Jayakody K., Arambage K. Wernicke's encephalopathy: a preventable cause of maternal death. Br J Hosp Med (Lond). 2011; 72 (1): 31-34. DOI: 10.12968/hmed.2011.72.1.31. PMID: 21240115.</mixed-citation><mixed-citation xml:lang="en">Wedisinghe L., Jayakody K., Arambage K. Wernicke's encephalopathy: a preventable cause of maternal death. Br J Hosp Med (Lond). 2011; 72 (1): 31-34. DOI: 10.12968/hmed.2011.72.1.31. PMID: 21240115.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Erick M. Gestational malnutrition, hyperemesis gravidarum, and Wernicke's encephalopathy: What is missing? Nutr Clin Pract. 2022; 37 (6): 1273-1290. DOI: 10.1002/ncp.10913. Epub 2022 Oct 17. PMID: 36250744.</mixed-citation><mixed-citation xml:lang="en">Erick M. Gestational malnutrition, hyperemesis gravidarum, and Wernicke's encephalopathy: What is missing? Nutr Clin Pract. 2022; 37 (6): 1273-1290. DOI: 10.1002/ncp.10913. Epub 2022 Oct 17. PMID: 36250744.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Смертина Л. П., Каспарова А. Э. Редкий клинический случай энцефалопатии Гайе – Вернике у беременной: вопросы диагностики и лечения. Вестник СурГУ. Медицина. 2020; 2 (44): 92-97.</mixed-citation><mixed-citation xml:lang="en">Smertina L. P., Kasparova A. E. A rare clinical case of Gayet-Wernicke encephalopathy in a pregnant woman: diagnostic and treatment issues. Vestnik SurGU. Medicina. Medicine. 2020; 2 (44): 92-97. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Fiorentini M., Nedu B., Dapoto F., Brunelli E., Pilu G., Youssef A. When time is brain: a systematic review about Wernicke encephalopathy as a dramatic consequence of thiamin deficiency in hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2023; 36 (2): 2223678. DOI: 10.1080/14767058.2023.2223678. PMID: 37322816.</mixed-citation><mixed-citation xml:lang="en">Fiorentini M., Nedu B., Dapoto F., Brunelli E., Pilu G., Youssef A. When time is brain: a systematic review about Wernicke encephalopathy as a dramatic consequence of thiamin deficiency in hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2023; 36 (2): 2223678.  DOI:  10.1080/14767058.2023.2223678. PMID: 37322816.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Silhadi S., Pinaud S. É., Nendaz M., Stirnemann J. Thiamine: une simple vitamine ? [Thiamin: Simply a vitamin?]. Rev Med Suisse. 2022; 18 (801): 2020-2023. French. DOI: 10.53738/REVMED.2022.18.801.2020. PMID: 36314092.</mixed-citation><mixed-citation xml:lang="en">Silhadi S., Pinaud S. É., Nendaz M., Stirnemann J. Thiamine: une simple vitamine ? [Thiamin: Simply a vitamin?]. Rev Med Suisse. 2022; 18 (801): 2020-2023. French.  DOI: 10.53738/REVMED.2022.18.801.2020. PMID: 36314092.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Stephens A., Patel K., Rao A., Browne P., Raley S., Street L. Recurrent Wernicke's encephalopathy in pregnancy: A case report. Nutr Neurosci. 2019; 22 (7): 528-530. DOI: 10.1080/1028415X.2017.1416941. Epub 2017 Dec 22. PMID: 29272216.</mixed-citation><mixed-citation xml:lang="en">Stephens A., Patel K., Rao A., Browne P., Raley S., Street L. Recurrent Wernicke's encephalopathy in pregnancy: A case report. Nutr Neurosci. 2019; 22 (7): 528-530. DOI: 10.1080/1028415X.2017.1416941. Epub 2017 Dec 22. PMID: 29272216.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
