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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2024.27.6.005</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1251</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НУТРИЦИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NUTRITIOLOGY</subject></subj-group></article-categories><title-group><article-title>Нутритивная поддержка коморбидных пациентов с астеническими состояниями</article-title><trans-title-group xml:lang="en"><trans-title>Nutritional support for comorbid patients with asthenic conditions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7629-3773</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акарачкова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Akarachkova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Акарачкова Елена Сергеевна, д.м.н., профессор, президент</p><p>115573, Москва, ул. Мусы Джалиля, 40</p><p>Красногорск</p></bio><bio xml:lang="en"><p>Elena S. Akarachkova, Dr. of Sci. (Med.), Professor, President </p><p>40 Musa Jalil str., Moscow, 115573</p><p>Krasnogorsk</p></bio><email xlink:type="simple">info@stressundercontrol.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4796-7334</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красноруцкая</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnorutskaya</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Красноруцкая Ольга Николаевна, д.м.н., доцент, декан</p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><bio xml:lang="en"><p>Olga N. Krasnorutskaya, Dr. of Sci. (Med.), Associate Professor, Dean</p><p>10 Studentskaya str., Voronezh, 394036</p></bio><email xlink:type="simple">89805520393onk@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4763-4153</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бугримов</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bugrimov</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бугримов Даниил Юрьевич, к.м.н., доцент</p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><bio xml:lang="en"><p>Daniil Yu. Bugrimov, Cand. of Sci. (Med.), Associate Professor</p><p>10 Studentskaya str., Voronezh, 394036</p></bio><email xlink:type="simple">danikst@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Международное сообщество «Стресс под контролем»; Реабилитационный центр Rehaline</institution><country>Россия</country></aff><aff xml:lang="en"><institution>International Community Stress under Control; Rehaline Rehabilitation Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Воронежский государственный медицинский университет имени Н. Н. Бурденко</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State Medical University named after N. N. Burdenko</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>10</day><month>06</month><year>2024</year></pub-date><volume>0</volume><issue>6</issue><fpage>37</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Акарачкова Е.С., Красноруцкая О.Н., Бугримов Д.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Акарачкова Е.С., Красноруцкая О.Н., Бугримов Д.Ю.</copyright-holder><copyright-holder xml:lang="en">Akarachkova E.S., Krasnorutskaya O.N., Bugrimov D.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1251">https://journal.lvrach.ru/jour/article/view/1251</self-uri><abstract><sec><title>Цель работы</title><p>Цель работы. В обзоре приведен анализ современной отечественной и зарубежной литературы о роли нутритивной поддержки у коморбидных пациентов с астенией. Обсуждается проблема пищевого дефицита витаминов группы В, в том числе в результате снижения их абсорбции, что может рассматриваться как этиологический фактор развития неврологических нарушений и широкого спектра патологических состояний, в том числе иммунных, усугубление течения которых наблюдается у разных групп населения, включая пожилых людей.</p></sec><sec><title>Результаты</title><p>Результаты. Нарастающее число пациентов с жалобами на астенические проявления в симптомокомплексе их основного заболевания не может не вызывать тревогу, поэтому авторы статьи приводят данные научных исследований, подтверждающих общую клиническую тенденцию – употребление достаточного количества витаминов В-комплекса положительно влияет на физические, психические и энергетические результаты у коморбидных пациентов. Отдельно в обзоре представлен анализ данных о необходимости включения в рацион питания витаминов группы В для коррекции соматопсихических проявлений стресса как в долгосрочной перспективе (влияние на производительность труда работников, сокращение количества дней нетрудоспособности, снижение уровня заболеваемости и несчастных случаев и проч.), так и сиюминутной потребности. Особо подчеркнута необходимость в дальнейших исследованиях нейрокогнитивных и физических преимуществ добавок не только В-комплексов, но и иных микронутриентов, в целом подтверждающих доказательства пользы нутритивной поддержки здоровых групп населения и групп риска с точки зрения физических, умственных и энергетических результатов. Подробный анализ данных статьи выявил необходимость рассмотреть современные данные экспериментальных и клинических исследований, патогенетические механизмы развития астенических явлений у пациентов с коморбидной патологией и возможные точки приложения нутритивной поддержки при их коррекции.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. The review provides an analysis of modern domestic and foreign literature on the role of nutritional support in comorbid patients with asthenia. The problem of dietary deficiency of B vitamins is discussed, including as a result of a decrease in their absorption, which can be considered as an etiological factor in the development of neurological disorders and a wide range of pathological conditions, including immune ones, the aggravation of which is observed in different groups of the population, including the elderly.</p></sec><sec><title>Results</title><p>Results. The growing number of patients with complaints of asthenic manifestations in the symptom complex of their underlying disease cannot but cause alarm, so the authors of the article provide data from scientific studies confirming the general clinical trend – the use of sufficient amounts of B-complex vitamins has a positive effect on physical, mental and energetic results in comorbid patientspatients. Separately, the review presents an analysis of data on the need to include B vitamins in the diet to correct the somatopsychic manifestations of stress both in the long term (impact on worker productivity, reducing the number of days of disability, reducing the level of morbidity and accidents, etc.) and short-term needs. The need for further research into the neurocognitive and physical benefits of not only B-complex supplementation, but also other micronutrients, is particularly emphasized, with overall supporting evidence for the benefits of nutritional support in healthy and at-risk populations in terms of physical, mental and energy outcomes. A detailed analysis of the data in the article revealed the need to consider modern data from experimental and clinical studies, the pathogenetic mechanisms of the development of asthenic phenomena in patients with comorbid pathology, and possible points of application of nutritional support in their correction.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>витамины группы В</kwd><kwd>дезоксирибонуклеат натрия</kwd><kwd>ДНК</kwd><kwd>нервная система</kwd><kwd>астенические явления</kwd></kwd-group><kwd-group xml:lang="en"><kwd>B vitamins</kwd><kwd>sodium deoxyribonucleate</kwd><kwd>DNA</kwd><kwd>nervous system</kwd><kwd>asthenic phenomena</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Naureen Z., Dhuli K., Medori M. C., Caruso P., Manganotti P., Chiurazzi P., Bertelli M. Dietary supplements in neurological diseases and brain aging. 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