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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2024.27.5.006</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1236</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДЕРМАТОВЕНЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMATOVENEROLOGY</subject></subj-group></article-categories><title-group><article-title>Опыт успешного применения топических бета-адреноблокаторов в терапии младенческих гемангиом: клинический случай и обзор литературы</article-title><trans-title-group xml:lang="en"><trans-title>Experience with the successful use of topical beta-adrenoblockers in the treatment of infantile hemangiomas: a clinical case and review of the literature</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9676-1581</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саранюк</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Saranyuk</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саранюк Роман Владимирович, президент Курской региональной общественной организации «Общество интегративной дерматологии», дерматовенеролог</p><p>305018, Россия, Курск, проспект Ленинского Комсомола, 2 </p></bio><bio xml:lang="en"><p>Roman V. Saranyuk, President of the Kursk regional public Organization«Society of Integrative Dermatology», dermatovenereologist</p><p>2 Leninsky Komsomol Avenue, Kursk, 305018, Russia </p></bio><email xlink:type="simple">roman.saranuk@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0059-9159</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гостева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gosteva</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гостева Татьяна Александровна, член Курской  региональной общественной организации «Общество интегративной дерматологии», терапевт, пульмонолог</p><p>Россия, 307250, Курская область, Курчатов, улица Энергетиков, 10 </p></bio><bio xml:lang="en"><p>Tatyana A. Gosteva, Member of the Kursk regional public organization «Society of Integrative Dermatology», therapist, pulmonologist</p><p>10 Energetikov Str., Kurchatov, Kursk region, 307250, Russia </p></bio><email xlink:type="simple">ya-lisenok-@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр медицинских осмотров и профилактики</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Limited Liability Company «Center for Medical Examinations and&#13;
Prevention»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Курчатовский центр современной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Limited Liability Company «Kurchatov Center of Modern Medicine»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>05</day><month>05</month><year>2024</year></pub-date><volume>0</volume><issue>5</issue><fpage>32</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Саранюк Р.В., Гостева Т.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Саранюк Р.В., Гостева Т.А.</copyright-holder><copyright-holder xml:lang="en">Saranyuk R.V., Gosteva T.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1236">https://journal.lvrach.ru/jour/article/view/1236</self-uri><abstract><p>Введение. Инфантильные (младенческие) гемангиомы являются доброкачественной сосудистой опухолью, встречающейся преимущественно в детской популяции. Ее наличие может приводить не только к эстетическому дискомфорту, но и к грубым функциональным нарушениям. Этиология младенческих гемангиом не до конца изучена. Предполагается, что в основе развития данного новообразования лежит аномальная пролиферация эндотелиальных клеток с нарушением архитектоники кровеносных сосудов вследствие мутации генов, отвечающих за процессы пролиферации тканей, либо как следствие антенатальной и/или перинатальной гипоксии. Несмотря на то что в некоторых случаях младенческие гемангиомы могут разрешаться самопроизвольно, вопрос об их терапии является актуальным и рассматривается в отношении каждого пациента индивидуально. На сегодняшний день первой линией терапии является прием бета-адреноблокатора – пропранолола с выраженным клиническим улучшением, но возможным развитием ряда побочных эффектов. Терапия инициируется в максимально ранние сроки, то есть в пролиферативной фазе развития инфантильной гемангиомы. Выбранный метод лечения должен быть максимально эффективным и не приводить к серьезным осложнениям и развитию побочных эффектов. Так как в литературе отсутствует единый подход к ведению таких пациентов, необходимо продолжать искать другие методы лечения инфантильной гемангиомы в зависимости от клинического и морфологического течения заболевания.Заключение. В данной статье представлен клинический случай инфантильной гемангиомы и результаты применения топического бета-адреноблокатора как альтернативный метод лечения для снижения риска развития побочных эффектов группы препаратов бета-адреноблокаторов.</p></abstract><trans-abstract xml:lang="en"><p>Background. Infantile (infantile) hemangiomas are benign vascular tumors found predominantly in the pediatric population. Its presence can lead not only to aesthetic discomfort of the child, but also to gross functional disorders. The etiology of infantile hemangiomas is not fully understood. It is assumed that the development of this neoplasm is based on abnormal proliferation of endothelial cells with disruption of the architectonics of blood vessels due to mutation of genes responsible for the processes of tissue proliferation, or as a consequence of antenotal and/or perinatal hypoxia. Despite the fact that in some cases infantile hemangiomas can resolve spontaneously, the question of their therapy is relevant and is considered in relation to each patient individually. To date, the first line of therapy is the administration of the beta-adrenoblocker propranolol, with marked clinical improvement, but possible development of a number of side effects. Therapy is initiated as early as possible, that is, during the proliferative phase of infantile hemangioma development. The chosen method of treatment should be as effective as possible and should not lead to serious complications and the development of side effects. Since there is no unified approach to the management of such patients in the literature, it is necessary to continue searching for other methods of infantile hemangioma treatment depending on the clinical and morphologic course of the disease.Conclusion. This article presents a clinical case of infantile hemangioma and the results of topical beta-blocker use as an alternative treatment method to reduce the risk of side effects of the beta-adrenoblocker group of drugs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфантильная (младенческая) гемангиома</kwd><kwd>бета-адреноблокаторы</kwd><kwd>тимолол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infantile hemangioma</kwd><kwd>b-adrenoblockers</kwd><kwd>timolol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кукес В. Г., Сычев Д. А., Андреев Д. А. Клиническая фармакология b-адреноблокаторов. РМЖ. 2005; 14: 932.</mixed-citation><mixed-citation xml:lang="en">Kukes V. G., Sychev D. A., Andreev D. A. Clinical pharmacology of b-adrenoblockers. Breast cancer. Russkiy meditsinskiy zhurnal. 2005; 14: 932. 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