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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2024.27.2.006</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1191</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ. ГЕПАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY. HEPATOLOGY</subject></subj-group></article-categories><title-group><article-title>Функциональная изжога: проблемы диагностики и лечения</article-title><trans-title-group xml:lang="en"><trans-title>Functional heartburn: problems of diagnosis and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7603-8481</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмедов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedov</surname><given-names>Vadim A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахмедов Вадим Адильевич, д.м.н., профессор, заведующий кафедрой медицинской реабилитации дополнительного профессионального образования, </p><p>644037, Россия, Омск, ул. Петра Некрасова, 5.</p></bio><bio xml:lang="en"><p>Vadim A. Akhmedov, Dr. of Sci. (Med.), Professor, Head of the Department of Medical Rehabilitation of Additional Professional Education,</p><p>5, Petr Nekrasov str., Omsk, 644037.</p></bio><email xlink:type="simple">v_akhmedov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9252-9152</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бикбавова</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bikbavova</surname><given-names>Galiya R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бикбавова Галия Равильевна, к.м.н., доцент кафедры госпитальной терапии, эндокринологии, </p><p>644037, Россия, Омск, ул. Петра Некрасова, 5.</p><p> </p></bio><bio xml:lang="en"><p>Galiya R. Bikbavova, Cand. of Sci. (Med.), Associate Professor of the Department of Hospital Therapy, Endocrinology,</p><p>5, Petr Nekrasov str., Omsk, 644037.</p></bio><email xlink:type="simple">galiya1976@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-0176-1032</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыбулькина</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsibulkina</surname><given-names>Maria S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цыбулькина Мария Сергеевна, студентка 6-го курса лечебного факультета, </p><p>644037, Россия, Омск, ул. Петра Некрасова, 5.</p><p> </p></bio><bio xml:lang="en"><p>Maria S. Tsibulkina, Student,</p><p>5, Petr Nekrasov str., Omsk, 644037.</p></bio><email xlink:type="simple">tsybulkinamaria@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Омский государственный медицинский университет Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education Omsk State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>03</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>31</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ахмедов В.А., Бикбавова Г.Р., Цыбулькина М.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ахмедов В.А., Бикбавова Г.Р., Цыбулькина М.С.</copyright-holder><copyright-holder xml:lang="en">Akhmedov V.A., Bikbavova G.R., Tsibulkina M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1191">https://journal.lvrach.ru/jour/article/view/1191</self-uri><abstract><sec><title>Введение</title><p>Введение. Функциональная изжога относится к широко распространенным заболеваниям желудочно-кишечного тракта. Для этой патологии характерна рефрактерная изжога, т. е. отсутствие ее купирования при оптимальном применении ингибиторов протонной помпы, что требует проведения дифференциальной диагностики с другими заболеваниями верхних отделов пищеварительного тракта. Функциональную изжогу связывают с частыми обращениями за медицинской помощью, необходимостью повторных обследований и, как следствие, увеличением страховых расходов. Однако существуют проблемы недостаточной информированности врачей о данном ззаболевании и отсутствия широкодоступного метода диагностики, что приводит к неэффективности лечения и снижению качества жизни пациентов. Болезнь нередко сопряжена с тревожными и депрессивными расстройствами, рост которых отмечается в последнее время, что требует своевременной диагностики и коррекции данных состояний. Ключевой частью патофизиологии функциональной изжоги является висцеральная гиперчувствительность, а психосоциальные факторы влияют на взаимодействия между нервной системой желудочно-кишечного тракта и головным мозгом, что определяет тяжесть симптомов у пациентов. Врачам рекомендуется подробно рассказывать пациентам о сути заболевания, направлениях возможного эффективного лечения для лучшей приверженности терапии, рекомендовано использование антидепрессантов, когнитивноповеденческой терапии, гипнотерапии и методов релаксации. На данный момент стандартом диагностики функциональной изжоги является pН-импедансометрия с первичным исключением органической патологии при эндоскопическом исследовании пищевода со взятием биопсии и проведением гистологического исследования и исключением нарушений моторики пищевода при проведении манометрии. Необходимы неинвазивные, доступные и экономически эффективные диагностические инструменты, чтобы избежать гипердиагностики гастроэзофагеальной рефлюксной болезни и неправильного использования игибиторов протонной помпы, перспективно исследование пепсина слюны и обследование пациента у стоматолога.</p></sec><sec><title>Цель работы</title><p>Цель работы. Обобщение данных проведенных исследований о распространенности функциональной изжоги, влиянии на ее течение психологических факторов, актуальных методах диагностики и лечения данной патологии. Чтобы выявить исследования, посвященные проблемам диагностики и лечения функциональной изжоги, был проведен поиск литературы в базах данных PubMed и eLibrary до ноября 2023 г., были просмотрены оригинальные статьи, метаанализы и соответствующие запросу обзоры.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Functional heartburn is one of the disorders of the gastrointestinal tract that is widespread in modern society. The disease is characterized by refractory symptoms of heartburn, lack of relief of symptoms with optimal use of proton pump inhibitors, which requires differential diagnosis with a number of diseases of the esophagus. Functional heartburn is associated with frequent medical treatment, repeated examinations, and increased insurance costs. At the same time, there is a problem of insufficient awareness of doctors about this disease, the lack of a widely available diagnostic method, which leads to a failure to receive effective treatment and a decrease in the quality of life of patients. The disease is often associated with anxiety and depressive disorders, the growth of which has been noted recently, which requires timely diagnosis and correction of these conditions. Visceral hypersensitivity is a key part of the pathophysiology of functional heartburn, and psychosocial factors influence interactions between the gastrointestinal nervous system and the brain, which determines the severity of symptoms in patients. Doctors are recommended to tell patients in detail about the essence of the diagnosis, directions in possible effective treatment, for better adherence to therapy, the use of antidepressants, cognitive behavioral therapy, hypnotherapy and relaxation methods is recommended. At the moment, the standard for the diagnosis of functional heartburn is pH-impedance measurement, with the primary exception of organic pathology during endoscopic examination of the esophagus with biopsy and histological examination, and the exclusion of esophageal motility disorders during manometry. Non-invasive, affordable and cost-effective diagnostic tools are needed to avoid overdiagnosis of gastroesophageal reflux disease and improper use of proton pump inhibitors, saliva pepsin examination and dental examination are promising.</p></sec><sec><title>Objective</title><p>Objective. The purpose of the review is to summarize the existing research data on the prevalence of functional heartburn, the influence of psychological factors on its course, and current methods of diagnosis and treatment of this pathology. In order to identify studies on the problems of diagnosis and treatment of functional heartburn, a literature search was conducted in the PubMed and eLibrary databases until November 2023, original articles, meta-analyses and relevant reviews were reviewed.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>функциональная изжога</kwd><kwd>рефрактерная гастроэзофагеальная рефлюксная болезнь</kwd><kwd>диагностика</kwd><kwd>pH-импедансометрия</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>functional heartburn</kwd><kwd>refractory gastroesophageal reflux disease</kwd><kwd>diagnosis</kwd><kwd>pH-impedance measurement</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Feldman M., Friedman L., Brandt L. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 11 ed. 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