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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2023.26.9.006</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1118</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕДИАТРИЯ. НЕОНАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PEDIATRICS. NEONATOLOGY</subject></subj-group></article-categories><title-group><article-title>Ферментация молочной основы с естественным образованием олигосахаридов грудного молока — новые возможности в адаптации детских смесей</article-title><trans-title-group xml:lang="en"><trans-title>Fermentation of the milk base with the natural formation of breast milk oligosaccharides — new opportunities in the adaptation of infant formula</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3741-8545</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комарова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Komarova</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Комарова Оксана Николаевна, к.м.н., гастроэнтеролог, диетолог</p><p>125412, Москва, ул. Талдомская, 2</p></bio><bio xml:lang="en"><p>Oxana N. Komarova, Cand. of Sci. (Med.), gastroenterologist, nutritionis</p><p>2, Taldomskaya str., Moscow, 125412</p></bio><email xlink:type="simple">komarovadoc@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данилова</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilova</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Данилова Алёна Игоревна, менеджер научно-медицинского отдела</p><p>143421, Московская область, Красногорский район, Новорижское шоссе, 26 км автодороги «Балтия», Бизнес-центр «Рига Ленд», стр. 1</p></bio><bio xml:lang="en"><p>Alena I. Danilova, Medical Manager</p><p>1 building of the Riga Land Business Center, 26 km of the Baltiya highway, Novorizhskoe highway, Krasnogorsky district, Moscow region, 143421</p></bio><email xlink:type="simple">alena.danilova@danone.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Обособленное структурное подразделение Научно-исследовательский клинический институт педиатрии и детской хирургии имени академика Ю. Е. Вельтищева Федерального государственного автономного образовательного учреждения высшего образования Российский национальный исследовательский медицинский университет имени Н. И. Пирогова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Separate structural subdivision of the Research Clinical Institute of Pediatrics and Pediatric Surgery named after Academician Yu. E. Veltischev of the Federal State Autonomous Educational Institution of Higher Education N. I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Общество с ограниченной ответственностью «Нутриция»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Nutricia Limited Liability Company</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>25</day><month>10</month><year>2023</year></pub-date><volume>0</volume><issue>9</issue><fpage>50</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Комарова О.Н., Данилова А.И., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Комарова О.Н., Данилова А.И.</copyright-holder><copyright-holder xml:lang="en">Komarova O.N., Danilova A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1118">https://journal.lvrach.ru/jour/article/view/1118</self-uri><abstract><sec><title>Введение</title><p>Введение. Грудное молоко является лучшим питанием для ребенка. При невозможности грудного вскармливания первостепенное значение имеет выбор детской молочной смеси. Важно, чтобы состав смеси отражал состав и эффекты грудного молока. Новым подходом к адаптации детской молочной смеси является особая технология ферментации молочной основы. Было продемонстрировано, что в результате ферментации происходит частичное расщепление макронутриентов, что способствует повышению биологической ценности и облегчает усвоение молочного продукта. Также в процессе ферментации молочной основы бактериальными штаммами образуются продукты их жизнедеятельности – различные метаболически активные соединения, постбиотики, которые приносят пользу для здоровья организму-хозяину.</p></sec><sec><title>Цель работы</title><p>Цель работы. Оценить представленные в национальной и международной литературе научные данные о биологической ценности ферментированных продуктов, влиянии процесса ферментации на макронутриенты, а также пользу использования ферментированной молочной основы в составе детской молочной смеси.</p></sec><sec><title>Результаты</title><p>Результаты. Анализ литературы демонстрирует высокую научную заинтересованность в обозреваемой теме. Польза ферментированных продуктов обусловлена, среди прочего, образованием активных метаболитов молочнокислых бактерий, постбиотиков. К классу постбиотиков можно отнести широкий спектр соединений, например: пептиды, аминокислоты, жирные кислоты, олигосахариды грудного молока и т. д. Качество и количество постбиотиков определяются типом бактерий, использованных для закваски продукта, а также особенностями технологии сквашивания. Использование частично ферментированной молочной основы для создания детской молочной смеси является инновационным подходом в адаптации заменителей грудного молока, потому что позволяет приблизиться к составу и эффектам грудного молока. Одним из постбиотиков, образующихся в результате ферментации Лактофидус™, является олигосахарид 3’-галактозиллактоза (3’-GL), идентичный по своей структуре и свойствам 3’-GL грудного молока. В ходе исследований in vivo и in vitro были показаны безопасность и хорошая переносимость детских смесей, содержащих 3’-GL, а также положительное воздействие их на организм ребенка на местном и системном уровнях, в частности, в сочетании с пребиотиками scGOS/lcFOS (9:1).</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Breast milk is the best nutrition for a baby. If breastfeeding is not possible, the choice of infant formula is of paramount importance. It is important that the composition of the formula reflects the composition and effects of breast milk. A new approach to adapting infant formula is a special technology for fermenting the milk base. It has been demonstrated that as a result of fermentation, partial breakdown of macronutrients occurs, which increases the biological value and facilitates the digestion of the dairy product. Also, during the fermentation of the milk base by bacterial strains, their metabolic products are formed – various metabolically active compounds, postbiotics, which bring health benefits to the host organism.</p></sec><sec><title>Objective</title><p>Objective. To evaluate the scientific evidence presented in the national and international literature on the biological value of fermented foods, the effect of the fermentation process on macronutrients, and the benefits of using a fermented milk base in infant formula.</p></sec><sec><title>Results</title><p>Results. Analysis of the literature demonstrates high scientific interest in the topic under review. The benefits of fermented foods are due, among other things, to the formation of active metabolites of lactic acid bacteria, postbiotics. The class of postbiotics includes a wide range of compounds, for example: peptides, amino acids, fatty acids, breast milk oligosaccharides, etc. The quality and quantity of postbiotics is determined by the type of bacteria used to ferment the product, as well as the characteristics of the ripening technology. The use of a partially fermented milk base to create infant formula is an innovative approach in adapting breast milk substitutes because it allows us to get closer to the composition and effect of breast milk. One of the postbiotics formed as a result of Lactofidus™ fermentation is the oligosaccharide 3’-galactosyllactose (3’-GL), identical in structure and properties to 3’-GL of breast milk. In vivo and in vitro studies have shown the safety and good tolerability of infant formulas containing 3'-GL, as well as their positive effects on the child’s body at the local and systemic levels, in particular, in combination with prebiotics scGOS/lcFOS (9:1).</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>заменители грудного молока</kwd><kwd>микробиота</kwd><kwd>олигосахариды грудного молока</kwd><kwd>ферментация</kwd><kwd>биотики</kwd><kwd>пребиотики</kwd><kwd>постбиотики</kwd><kwd>3’-галактозиллактоза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infant formula</kwd><kwd>microbiota</kwd><kwd>human milk oligosaccharides</kwd><kwd>fermentation</kwd><kwd>biotics</kwd><kwd>prebiotics</kwd><kwd>postbiotics</kwd><kwd>3’-galactosyllactose</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ballard O., Morrow A. L. 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