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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name>ООО «Издательство "Открытые системы"»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2022.25.12.007</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1003</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Особенности патологии эндометрия в пременопаузальном периоде</article-title><trans-title-group xml:lang="en"><trans-title>The characteristics of the endometrial pathology in premenopausal period</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6274-6834</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиева</surname><given-names>Ф. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Aliyeva</surname><given-names>F. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алиева Фидан Тарлан кызы, аспирант кафедры акушерства и гинекологии</p><p>119991, Москва, ул. Трубецкая, 8/2</p></bio><bio xml:lang="en"><p>Fidan T. Aliyeva, PhD student of the Department of Obstetrics and Gynecology</p><p>8/2 Trubetskaya str., Moscow, 119991</p></bio><email xlink:type="simple">fidan.alieva.95@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5969-4217</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брюнин</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bryunin</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Брюнин Дмитрий Викторович, доктор медицинских наук, профессор, заведующий гинекологическим отделением</p><p>119435, Россия, Москва, ул. Еланского, 2, стр. 1</p></bio><bio xml:lang="en"><p>Dmitry V. Bryunin, Dr. of Sci. (Med.), Professor, Head of the Gynecological Department</p><p>2/1 Elansky str., Moscow, 119435</p></bio><email xlink:type="simple">mic_amu@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education Sechenov First Moscow State University of Medicine of Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Клиника акушерства и гинекологии им. В. Ф. Снегирева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinic of Obstetrics and Gynecology named after V. F. Snegirev</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>01</month><year>2023</year></pub-date><volume>0</volume><issue>12</issue><fpage>41</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алиева Ф.Т., Брюнин Д.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Алиева Ф.Т., Брюнин Д.В.</copyright-holder><copyright-holder xml:lang="en">Aliyeva F.T., Bryunin D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1003">https://journal.lvrach.ru/jour/article/view/1003</self-uri><abstract><p>Целью данного исследования было изучить частоту патологии эндометрия и ее клинические проявления в пременопаузальном периоде. Обследованы 73 женщины с различной патологией эндометрия в пременопаузальном периоде. Средний возраст обследованных составил 47,82 ± 0,27 (45-51) года. Изучение менструальной и репродуктивной функции позволило установить, что менархе у женщин с различной патологией эндометрия в пременопаузальном периоде отмечалось с 11,0 ± 0,15 (11-17) года, длительность менструального цикла была в пределах 27,24 ± 0,47 (21-45) дня, длительность менструаций – 5,1 ± 0,14 (3-8) дня. Половая жизнь началась с 19,5 ± 0,57 (16-31) года. Количество беременностей – 5,2 ± 0,02 (1-10), родов – 1,72 ± 0,11 (1-4), медицинских абортов – 1,57 ± 0,11 (1-4), самопроизвольных выкидышей – 191 ± 0,34 (1-4). Всем больным с патологией эндометрия, находящимся в пременопаузальном периоде, были проведены клинические, функциональные, гормональные, а также эндоскопические, микробиологические, морфологические исследования. Полученные результаты были подвергнуты статистической обработке с применением стандартных компьютерных программ Statgraph, предназначенных для параметрических и непараметрических способов расчета средних значений. Установлено, что у 44,9% больных отмечалась полименорея, у 29% – меноррагия, у 21,7% – ациклические кровянистые выделения, у 20,3% – опсоменорея, у 17,4% – мажущие кровянистые выделения из половых путей, у 17,4% – боли в низу живота и пояснице, у 13% больных выявлена пройоменорея. У 54,8% женщин патология эндометрия в пременопаузальном периоде проявлялась полипом эндометрия (при этом у 45,2% больных диагностировался железисто-фиброзный полип эндометрия), у 20,5% – гиперплазия эндометрия, у 13% – наличием эндометрита, у 9,6% – субмукозной лейомиомой матки с диффузной гиперплазией эндометрия. Частота высокодифференцированной карциномы эндометрия составила 2,7%. Таким образом, у женщин с патологией эндометрия, находящихся в пременопаузальном периоде, отмечается достаточно высокая частота нарушений менструального цикла в сочетании с маточной патологией, требующей динамического наблюдения для предотвращения развития осложнений и злокачественных новообразований.</p></abstract><trans-abstract xml:lang="en"><p>The goal of study was to study the incidence and the clinical manifestation of the endometrial pathology in premenopausal period. 73 premenopausal women with various endometrial pathology were examined. The average age of the examined was 47.82 ± 0.27 (45-51) years. The age of the menarche was 11.0 ± 0.15 (11-17) years, with the duration of the menstrual cycle 27.24 ± 0.47 (21-45) days and menstruation 5.1 ± 0.14 (3-8) grays. Onset of sexual activity was at age 19.5 ± 0.57 (16-31) years. The number of pregnancies was 5.2 ± 0.02 (1-10), from which 1.72 ± 0.11 (1-4) terminated with vaginal births, 1.57 ± 0.11 (1-4) with medical abortions, and 1.91 ± 0.34 (1-4) with spontaneous abortions. All the patients were conducted clinical, functional, hormonal, endoscopic, morphological methods of examination. The results obtained were subjected to statistical processing using standard computer programs "Statgraph", designed for parametric and non-parametric methods for calculating average values. There was confirmed that 5.5% of patients with various pathology of the endometrium had no clinical symptoms. 44.9% of examined had polymenorrhea, 29% menorrhagia, 21.7% metrorrhagia, 20.3% opsomenorrhea, 17.4% bloody spotting from the vagina, 17.4% of patients had lower abdominal pain and 13% had proyomenorrhea. Among the types of the endometrial pathology in the premenopausal period there was prevalence in the endometrial polyp, in 54.8% of patients (at the same time, a glandular-fibrous polyp of the endometrium was diagnosed in 45.2% of patients). 22.5% of examined had endometrial hyperplasia, 13% endometritis, and 9.6% combination of uterine Myoma and endometrial hyperplasia. The incidence of high grade endometrial cancer was 2.7%. Thus, in women with endometrial pathology, who are in the is a fairly high frequency of menstrual irregularities in combination with uterine pathology, which requires dynamic monitoring to prevent the development of complications and malignant neoplasms.premenopausal period, there  is a fairly high frequency of menstrual irregularities in combination with uterine pathology, which requires dynamic monitoring to prevent the development of complications and malignant neoplasms.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пременопаузальный период</kwd><kwd>патология эндометрия</kwd><kwd>гиперплазия эндометрия</kwd><kwd>полип эндометрия</kwd><kwd>высокодифференцированная аденокарцинома эндометрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>premenopausal period</kwd><kwd>endometrial polyp</kwd><kwd>endometrial hyperplasia</kwd><kwd>highly differentiation endometrial carcinoma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Colombo N., Preti E., Landoni F., Carinelli S., Colombo A. 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