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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name>ООО «Издательство "Открытые системы"»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2022.25.12.005</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Особенности локализации, частоты встречаемости и сочетанности эндометриоидных поражений при рецидивирующем наружном генитальном эндометриозе</article-title><trans-title-group xml:lang="en"><trans-title>Features of localization, frequency of occurrence and combination of endometrioid lesions in recurrent external genital endometriosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1789-9182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиева</surname><given-names>Ф. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Aliyeva</surname><given-names>F. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алиева Фарах Тарлан кызы, аспирант кафедры акушерства и гинекологии</p><p>119991, Москва, ул. Трубецкая, 8/2</p></bio><bio xml:lang="en"><p>Farakh T. Aliyeva, PhD student of the Department of Obstetrics and Gynecology</p><p>8/2 Trubetskaya str., Moscow, 119991</p></bio><email xlink:type="simple">fereh.alieva.95@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5969-4217</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брюнин</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bryunin</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Брюнин Дмитрий Викторович, доктор медицинских наук, профессор, заведующий гинекологическим отделением</p><p>119435, Москва, ул. Еланского, 2, стр. 1</p></bio><bio xml:lang="en"><p>Dmitry V. Bryunin, Dr. of Sci. (Med.), Professor, Head of the Gynecological Department</p><p>2/1 Elansky str., Moscow, 119435</p></bio><email xlink:type="simple">mic_amu@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education Sechenov First Moscow State University of Medicine of Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Клиника акушерства и гинекологии им. В. Ф. Снегирева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinic of Obstetrics and Gynecology named after V. F. Snegirev</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>02</day><month>01</month><year>2023</year></pub-date><volume>0</volume><issue>12</issue><fpage>32</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алиева Ф.Т., Брюнин Д.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Алиева Ф.Т., Брюнин Д.В.</copyright-holder><copyright-holder xml:lang="en">Aliyeva F.T., Bryunin D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1001">https://journal.lvrach.ru/jour/article/view/1001</self-uri><abstract><p>Эндометриоз является хроническим, дисгормональным, иммунозависимым заболеванием с характерным разрастанием ткани, схожей по морфологическому строению с эндометрием и располагающейся за пределами слизистой оболочки эндометрия. Исследование предпринималось с целью изучения особенностей локализаций и сочетанности эндометриоидных поражений при рецидивирующем наружном генитальном эндометриозе. Обследованы 48 больных с рецидивирующим наружным генитальным эндометриозом, средний возраст – 34,96 ± 1,1 года (от 19 до 50 лет). Менархе отмечалось в 13,8 ± 1,9 года, продолжительность менструального цикла – 28,75 ± 0,53 (23-45) дня, длительность менструации составила 5,65 ± 0,17 (3-10) дня. Начало половой жизни у больных отмечалось с 18,98 ± 0,39 (15-30) года. Длительность наружного генитального эндометриоза у больных с его рецидивирующими формами составила 10,0 ± 1,41 (9-11) года. Частота рецидива в среднем колебалась в пределах 2,02 ± 0,44 (1-4) года. Ремиссия в среднем длилась 6,1 ± 0,84 (1-15) года. Всем больным были проведены клинические, функциональные, эндоскопические, иммунологические и морфологические исследования. Установлено, что рецидивирующий наружный генитальный эндометриоз в 35,7% случаев проявляется наличием эндометриоидных кист яичников, в 24,6% – эндометриоидных инфильтратов крестцово-маточных связок, в 10,3% – эндометриозом тазовой брюшины, в 7,1% – эндометриозом крестцово-маточных связок, в 6,3% – наличием ретроцервикального эндометриоидного инфильтрата, в 5,6% – эндометриозом яичников, в 4,8% – эндометриозом пузырно-маточной складки брюшины. Изучение сочетанности и распространенности эндометриоидных поражений при рецидивирующем наружном генитальном эндометриозе позволило установить наличие II стадии распространения эндометриоидного процесса по классификации А. И. Ищенко (1993). При этом у 27,1% больных отмечалось сочетание эндометриоидной кисты яичника и эндометриоидных инфильтратов крестцово-маточных связок, у 14,8% – с эндометриозом крестцово-маточных связок, у 8,3% – с эндометриозом крестцово-маточных связок и эндометриозом другого яичника.</p></abstract><trans-abstract xml:lang="en"><p>Endometriosis is a chronic, dyshormonal, immune-dependent disease with a characteristic proliferation of tissue similar in morphological structure to the endometrium and located outside the endometrial mucosa. The goal of investigation was to study the peculiarities of localizations and combinations of endometrioid lesions in recurrent external genital endometriosis. 48 patients with recurrent external genital endometriosis were examined. The average age of the examined was 34.96 ± 1.1 years and ranged from 19 to 50 years. The study of the menstrual function made it confirmed that menarche was observed from 13.8 ± 1.9 years, the duration of the menstrual cycle was within 28.75 ± 0.53 (23-45) days, the duration of menstruation was 5.65 ± 0.17 (3-10) days. The onset of sexual activity in patients was noted from 18.98 ± 0.39 (15-30) years. The duration of endometriosis in patients with recurrent forms of external genital endometriosis was 10.0 ± 1.41 (9-11) years. The recurrence rate averaged 2.02 ± 0.44 (1-4) years. The duration of remission was 6.1 ± 0.84 (1-15) years on average. All patients underwent clinical, functional, endoscopic, immunological and morphological methods of examination. It was found out that recurrent external genital endometriosis in 35.7% of cases is manifested by the relapse of endometrioid ovarian cysts, in 24.6% by the presence of endometrioid infiltrates of the sacro-uterine ligaments, in 10.3% of cases by endometriosis of the pelvic peritoneum, in 7.1% of cases by endometriosis of sacro-uterine ligaments, in 6.3% of the presence of retrocervical endometrioid infiltrate, in 5.6% by ovarian endometriosis, in 4.8% of cases by endometriosis of the vesicouterine fold of the peritoneum. The study of the combination and dissemination of endometrioid lesions in recurrent external genital endometriosis demonstrated the presence of stage II of the pathological process according to the classification by A.I. Ishchenko (1993). At the same time, 27.1% of patients had a combination of endometrioid ovarian cyst and endometrioid infiltrates of the sacro-uterine ligaments, 14.8% endometriosis of the sacro-uterine ligaments, 8.3% of patients had endometriosis of the sacro-uterine ligaments and election of the unilateral ovary.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндометриоз</kwd><kwd>рецидивирующий наружный генитальный эндометриоз</kwd><kwd>эндометриоидная киста яичника</kwd><kwd>эндометриоидный инфильтрат</kwd><kwd>эндометриоз тазовой брюшины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endometriosis</kwd><kwd>recurrent external genital endometriosis</kwd><kwd>endometrioid ovarian cyst</kwd><kwd>endometrioid infiltrate of the sacro-uterine ligaments</kwd><kwd>endometrioid infiltrate</kwd><kwd>endometriosis of the pelvic peritoneum</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Солопова А. Г., Ачкасова Е. Е., Москвичева В. С., Григорьевская Е. Наружный генитальный эндометриоз: вопросы лечения и реабилитации // Акушерство, гинекология и репродукция. 2021; 1 (15): 70-79.</mixed-citation><mixed-citation xml:lang="en">Solopova A. G., Achkasova E. E., Moskvicheva V. S., Grigorievskaya E. External genital endometriosis: issues of treatment and rehabilitation // Obstetrics, Gynecology and Reproduction, 2021; 1 (15): 70-79.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Фролова И. Л., Цахилова С. Г., Смирнова Л. Е., Насрединова В. В. Современные аспекты эндометриоза // Проблемы репродукции. 2019; 5 (25): 30-35.</mixed-citation><mixed-citation xml:lang="en">Frolova I. L., Tsakhilova S. G., Smirnova L. E., Nasredinova V. V. Modern aspects of endometriosis // Problems of reproduction. 2019; 5 (25): 30-35.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Marinho M. C. P., Magalhaes T. F., Fernandes L. F. C. Quality of life in women with endometriosis: an integrative review // J. Womens Health. 2018; 3 (27): 399-408.</mixed-citation><mixed-citation xml:lang="en">Marinho M. C. P., Magalhaes T. F., Fernandes L. F. C. Quality of life in women with endometriosis: an integrative review // J. Womens Health. 2018; 3 (27): 399-408.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Parasar P., Ozcan P., Kathryn L. Endometriosis: Epidemiology, Diagnosis and Clinical Management // Curr Obstet Gynecol Rep. 2017; 6 (1): 34-41. DOI: 10.1007/s13669-017-0187-1.</mixed-citation><mixed-citation xml:lang="en">Parasar P., Ozcan P., Kathryn L. Endometriosis: Epidemiology, Diagnosis and Clinical Management // Curr Obstet Gynecol Rep. 2017; 6 (1): 34-41. DOI: 10.1007/s13669-017-0187-1.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Shah D. K., Correia K. F., Vitonis A. F., Missmer S. A. Body size and endometriosis: results from 20 years of follow-up within the Nurses’ Health Study II prospective cohort // Hum Reprod. 2013; 28 (7): 1783-1792. [PubMed: 23674552].</mixed-citation><mixed-citation xml:lang="en">Shah D. K., Correia K. F., Vitonis A. F., Missmer S. A. Body size and endometriosis: results from 20 years of follow-up within the Nurses’ Health Study II prospective cohort // Hum Reprod. 2013; 28 (7): 1783-1792. PubMed: 23674552.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ефименко Т. О. Структура, характер и интенсивность болевого синдрома при различных формах наружного генитального эндометриоза // Ж. Акушерства и женских болезней. 2016; 2 (65): 24-30.</mixed-citation><mixed-citation xml:lang="en">Efimenko T. O. The structure, nature and intensity of pain in various forms of external genital endometriosis // J. Obstetrics and female diseases. 2016; 2 (65): 24-30.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Закирова Я. Р., Бабаева Э. И, Оразов М. Р., Арютин Д. Г. Комплексная оценка репродуктивного здоровья пациенток с наружным генитальным эндометриозом после хирургического лечения // Человек. Спорт. Медицина. 2016; 4 (16): 32-42.</mixed-citation><mixed-citation xml:lang="en">Zakirova Ya. R., Babaeva E. I., Orazov M. R., Aryutin D. G. Comprehensive assessment of the reproductive health of patients with external genital endometriosis after surgical treatment // Chelоvek. Sport. Medicine. 2016; 4 (16): 32-42.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Солопова А. Г., Макацария А. Д., Чуканова Е. М. Эндометриоз: новый пожход к патогенезу // Эндометриоз: новый подход к патогенезу // Georgian Med. News. 2017; 12: 7-11.</mixed-citation><mixed-citation xml:lang="en">Solopova A. G., Makatsaria A. D., Chukanova E. M. Endometriosis: a new approach to pathogenesis // Endometriosis: a new approach to pathogenesis // Georgian Med. News. 2017; 12: 7-11.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mishra V. V., Bandwal P., Agarwal R., Aggarwal R. Prevalence, clinical and laparoscopic features of endometriosis among infertile women // J. Obstet. Gynecol India. 2017; 3 (67): 208-213.</mixed-citation><mixed-citation xml:lang="en">Mishra V. V., Bandwal P., Agarwal R., Aggarwal R. Prevalence, clinical and laparoscopic features of endometriosis among infertile women // J. Obstet. Gynecol India. 2017; 3 (67): 208-213.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Борисова А. В., Козаченко А. В. Факторы риска развития рецидива наружного генитального эндометриоза // Медицинский совет. 2018; 7: 32-38.</mixed-citation><mixed-citation xml:lang="en">Borisova A. V., Kozachenko A. V. Risk factors for the development of recurrence of external genital endometriosis // Medical Council. 2018; 7: 32-38.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Marki G., Bokor A., Rigo J., Rigo A. Physical pain and emotion regulation as the main prodicictive factors of health-related quality of life in women living with endometriosis // Hum.Reprod. 2017; 7 (32): 1432-1438.</mixed-citation><mixed-citation xml:lang="en">Marki G., Bokor A., Rigo J., Rigo A. Physical pain and emotion regulation as the main prodicictive factors of health-related quality of life in women living with endometriosis // Hum.Reprod. 2017; 7 (32): 1432-1438.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Melki E. Endometriosis treatment with shock waves: A novel approach // Med. Hypotheses. 2019; 124: 114-117. doi.org/10.1016/j.mehy.2019.02.022.</mixed-citation><mixed-citation xml:lang="en">Melki E. Endometriosis treatment with shock waves: A novel approach // Med. Hypotheses. 2019; 124: 114-117. doi.org/10.1016/j.mehy.2019.02.022.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz A. S., Gross E., Geraedts K. The use of home remedies and complementary health approaches in endometriosis // Reprod.Biomed.Online. 2019; 2 (38): 260-272. doi.org/10.1016/j.rbmo.2018.10.009.</mixed-citation><mixed-citation xml:lang="en">Schwartz A. S., Gross E., Geraedts K. The use of home remedies and complementary health approaches in endometriosis // Reprod.Biomed.Online. 2019; 2 (38): 260-272. doi.org/10.1016/j.rbmo.2018.10.009.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chalermcgockchareonkit A., Tekasakul P. Chaisilwattana P. Laparoscopic hysterectomy versus abdominal hysterectomy for severe pelvic endometriosis // Int J. Gynecol. Obstet. 2012; 116: 109-111.</mixed-citation><mixed-citation xml:lang="en">Chalermcgockchareonkit A., Tekasakul P. Chaisilwattana P. Laparoscopic hysterectomy versus abdominal hysterectomy for severe pelvic endometriosis // Int J. Gynecol. Obstet. 2012; 116: 109-111.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rizk B., Fischer A. S., Lotfy H. A., Turki R. Recurrence of endometriosis after hysterectomy // Facts Views Vis Obgyn. 2014; 6 (4): 219-227.</mixed-citation><mixed-citation xml:lang="en">Rizk B., Fischer A. S., Lotfy H. A., Turki R. Recurrence of endometriosis after hysterectomy // Facts Views Vis Obgyn. 2014; 6 (4): 219-227.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ищенко А. И. Патогенез, клиника, диагностика и оперативное лечение распространенных форм генитального эндометриоза: автореф. дис. … д. м.н. М., 1993.</mixed-citation><mixed-citation xml:lang="en">Ishchenko A. I. Pathogenesis, clinical picture, diagnosis and surgical treatment of common forms of genital endometriosis: author. dis. ... Doctor of Medical Sciences. M., 1993.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
